Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade

• Published in: Cancer letters Vol. 370; no. 1; pp. 153 - 164
• Main Authors: Chen, Zhaolin, Shi, Tianlu, Zhang, Lei, Zhu, Pengli, Deng, Mingying, Huang, Cheng, Hu, Tingting, Jiang, Ling, Li, Jun
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-01-2016
• Subjects: ABC transporters; Animals; ATP-Binding Cassette Transporters - antagonists & inhibitors; ATP-Binding Cassette Transporters - chemistry; ATP-Binding Cassette Transporters - physiology; Cancer therapy; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epigenesis, Genetic; Hematology, Oncology and Palliative Medicine; Humans; Inhibitors; Multidrug resistance; microRNAs; TMD0; YC-1; small interfering RNA; DNMT; (−)-epigallocatechin-3-gallate; shRNA; short hairpin RNA; VEGFR; MDR; P-gp/ABCB1; RNAi; breast cancer resistance protein; transmembrane domains; EGCG; TKIs; RUNX3; 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole; cMOAT; nucleotide-binding domains; Inhibitors; SFRP5; ATP-binding cassette; DNA methyltransferase; secreted frizzle-related protein 5; long non-coding RNAs; HDAC; lncRNAs; multidrug resistance; ABC; RNA interference; 3′-untranslated region; BrTet; COX-2; miRNAs; photodynamic therapy; NBDs; EGFR; 5-bromotetrandrine; TMDs; tyrosine kinase inhibitors; NRF2; terminal transmembrane domain; DVL1; dishevelled-1; NF-E2-related factor 2; ABC transporters; FZD1; Frizzled-1; PDT; breakpoint cluster region-Abelson; multidrug resistance-associated protein 2; epidermal growth factor receptor; FZD7; BCR-ABL; 3′-UTR; Frizzled-7; Runt-related transcription factor 3; siRNA; histone-lysine N-methyltransferase; BCRP/ABCG2; cyclo-oxygenase-2; histone deacetylase; BMP4; P-glycoprotein; Cancer therapy; adenosine triphosphate; MRP2/ABCC2; vascular endothelial growth factor receptor; canalicular multispecific organic anion transporter; ATP; bone morphogenetic protein 4; EZH2; Multidrug resistance
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2015.10.010

Highlights • Overview of ABC transporters in the role of MDR. • Inhibitors of ABC transporters will be useful tools in the modulation of MDR. • Recent developments of RNA interference which involved in ABC transporter-mediated MDR. • Epigenetic regulators exhibit effective function on the ABC transporter-mediated MDR.