New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities

Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activit...

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 51; no. 2; p. 145
Main Authors:	Dekker, K A, Inagaki, T, Gootz, T D, Huang, L H, Kojima, Y, Kohlbrenner, W E, Matsunaga, Y, McGuirk, P R, Nomura, E, Sakakibara, T, Sakemi, S, Suzuki, Y, Yamauchi, Y, Kojima, N
Format:	Journal Article
Language:	English
Published:	Japan 01-02-1998
Subjects:	4-Quinolones Actinomycetaceae Anti-Infective Agents - chemistry Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology Fermentation Helicobacter pylori - drug effects Microbial Sensitivity Tests Structure-Activity Relationship
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Summary:	Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.51.145