Long-Term Outcomes After Management of Restenosis or Thrombosis of Drug-Eluting Stents

• Published in: Journal of the American College of Cardiology Vol. 49; no. 2; pp. 181 - 184
• Main Authors: Mishkel, Gregory J., MD, FACC, Moore, Anna L., MPH, Markwell, Steve, MA, Shelton, M. Coleman, Shelton, Marc E., MD, FACC
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 16-01-2007; Elsevier Science; Elsevier Limited
• Subjects: Aged; Angioplasty; Angioplasty, Balloon, Coronary - adverse effects; Angioplasty, Balloon, Coronary - instrumentation; Angioplasty, Balloon, Coronary - methods; Angioplasty, Balloon, Coronary - mortality; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Cause of Death; Coronary Angiography; Coronary Restenosis - diagnostic imaging; Coronary Restenosis - etiology; Coronary Restenosis - mortality; Coronary Restenosis - therapy; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - mortality; Coronary Stenosis - therapy; Coronary vessels; Drug Delivery Systems; Equipment Failure; Female; Heart attacks; Humans; Internal Medicine; Male; Medical sciences; Middle Aged; Probability; Prognosis; Retreatment; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sirolimus - pharmacology; Stents; Stents - adverse effects; Survival Rate; drug-eluting stents; target lesion revascularization; in-stent restenosis; STH; bare-metal stent(ing); myocardial infarction; BMS; ISR; percutaneous coronary intervention; DES; MACE; stent thrombosis; PCI; STEMI; ST-segment elevation myocardial infarction; TLR; major adverse cardiovascular events; MI; Vascular disease; Restenosis; Prognosis; Cardiovascular disease; Evolution; Circulatory system; Cardiology; Long term; Phlebology; Thrombosis; Drug eluting stent
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2006.08.049

Long-Term Outcomes After Management of Restenosis or Thrombosis of Drug-Eluting Stents Gregory J. Mishkel, Anna L. Moore, Steve Markwell, M. Coleman Shelton, Marc E. Shelton While the incidence of restenosis has markedly decreased since the introduction of drug-eluting stents (DES), its optimal management remains unclear. Therefore, we sought to examine the outcomes of 92 patients who developed coronary in-stent restenosis (ISR) (n = 87) or thrombosis (n = 5) inside a DES. Patients were treated by either the “stent sandwich” or other percutaneous techniques. Over a mean follow-up of 15 ± 6 months, the overall rates of death, myocardial infarction, and target lesion revascularization were 8.7%, 2.2%, and 30.6%, respectively. The interventional treatment of ISR or thrombosis within DES remains problematic due to high long-term adverse event rates.