Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells

A grabby substrate: A 3D nanostructured substrate, namely, a silicon‐nanopillar (SiNP) array coated with epithelial‐cell adhesion‐molecule antibody (anti‐EpCAM), shows enhanced local topographic interactions between nanoscale cell‐surface components and the substrates surface, resulting in enhanced...

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Published in:Angewandte Chemie (International ed.) Vol. 48; no. 47; pp. 8970 - 8973
Main Authors: Wang, Shutao, Wang, Hao, Jiao, Jing, Chen, Kuan-Ju, Owens, Gwen E, Kamei, Ken-ichiro, Sun, Jing, Sherman, David J, Behrenbruch, Christian P, Wu, Hong, Tseng, Hsian-Rong
Format: Journal Article
Language:English
Published: Weinheim Wiley-VCH Verlag 01-01-2009
WILEY-VCH Verlag
WILEY‐VCH Verlag
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Abstract A grabby substrate: A 3D nanostructured substrate, namely, a silicon‐nanopillar (SiNP) array coated with epithelial‐cell adhesion‐molecule antibody (anti‐EpCAM), shows enhanced local topographic interactions between nanoscale cell‐surface components and the substrates surface, resulting in enhanced cell‐capture efficiency when employed to isolate viable cancer cells from whole‐blood samples (see schematic and SEM image of a captured cancer cell).
AbstractList A grabby substrate: A 3D nanostructured substrate, namely, a silicon‐nanopillar (SiNP) array coated with epithelial‐cell adhesion‐molecule antibody (anti‐EpCAM), shows enhanced local topographic interactions between nanoscale cell‐surface components and the substrates surface, resulting in enhanced cell‐capture efficiency when employed to isolate viable cancer cells from whole‐blood samples (see schematic and SEM image of a captured cancer cell).
Author Kamei, Ken-ichiro
Tseng, Hsian-Rong
Jiao, Jing
Chen, Kuan-Ju
Wang, Shutao
Sherman, David J
Behrenbruch, Christian P
Sun, Jing
Wu, Hong
Owens, Gwen E
Wang, Hao
Author_xml – sequence: 1
  fullname: Wang, Shutao
– sequence: 2
  fullname: Wang, Hao
– sequence: 3
  fullname: Jiao, Jing
– sequence: 4
  fullname: Chen, Kuan-Ju
– sequence: 5
  fullname: Owens, Gwen E
– sequence: 6
  fullname: Kamei, Ken-ichiro
– sequence: 7
  fullname: Sun, Jing
– sequence: 8
  fullname: Sherman, David J
– sequence: 9
  fullname: Behrenbruch, Christian P
– sequence: 10
  fullname: Wu, Hong
– sequence: 11
  fullname: Tseng, Hsian-Rong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/19847834$$D View this record in MEDLINE/PubMed
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Snippet A grabby substrate: A 3D nanostructured substrate, namely, a silicon‐nanopillar (SiNP) array coated with epithelial‐cell adhesion‐molecule antibody...
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SubjectTerms Antibodies, Immobilized - immunology
Antibodies, Immobilized - metabolism
Antigens, Neoplasm - metabolism
cancer diagnosis
Cell Adhesion Molecules - metabolism
cell capture
Cell Line, Tumor
Epithelial Cell Adhesion Molecule
Fluorescent Dyes - chemistry
Humans
Indoles - chemistry
Microscopy, Electron, Scanning
nanostructures
Nanostructures - chemistry
silicon
Silicon - chemistry
Title Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.200901668
https://www.ncbi.nlm.nih.gov/pubmed/19847834
https://pubmed.ncbi.nlm.nih.gov/PMC2878179
Volume 48
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