Effects of oral glucosamine hydrochloride administration on plasma free amino acid concentrations in dogs

• Published in: Marine drugs Vol. 9; no. 5; pp. 712 - 718
• Main Authors: Azuma, Kazuo, Osaki, Tomohiro, Tsuka, Takeshi, Imagawa, Tomohiro, Okamoto, Yoshiharu, Takamori, Yoshimori, Minami, Saburo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-05-2011; Molecular Diversity Preservation International
• Subjects: Acetylglucosamine - pharmacology; Administration, Oral; amino acid; Amino Acids - blood; Animals; Collagen Type II - biosynthesis; dog; Dogs; Glucosamine - administration & dosage; Glucosamine - pharmacology; glucosamine hydrochloride; Glucose - pharmacology; N-acetyl-D-glucosamine; Proteoglycans - biosynthesis; amino acid; dog; glucosamine hydrochloride; N-acetyl-d-glucosamine
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md9050712

We examined the effects of oral glucosamine hydrochloride (GlcN), N-acetyl-D-glucosamine (GlcNAc) and d-glucose (Glc) administration on plasma total free amino acid (PFAA) concentrations in dogs. The PFAA concentrations increased in the control group and the GlcNAc group at one hour after feeding, and each amino acid concentration increased. On the other hand, in the GlcN group and the Glc group PFAA concentrations decreased at one hour after feeding. A significant decrease in amino acid concentration was observed for glutamate, glycine and alanine. Our results suggest the existence of differences in PFAA dynamics after oral administration of GlcN and GlcNAc in dogs.