Coffee Consumption and Risk of Cardiovascular Diseases and All-Cause Mortality Among Men With Type 2 Diabetes

• Published in: Diabetes care Vol. 32; no. 6; pp. 1043 - 1045
• Main Authors: Zhang, Weili, Lopez-Garcia, Esther, Li, Tricia Y, Hu, Frank B, van Dam, Rob M
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01-06-2009
• Subjects: Adult; Aged; Biological and medical sciences; Caffeine; Caffeine - adverse effects; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - mortality; Coffee; Coffee - adverse effects; Cohort Studies; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - mortality; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding Behavior; Health risk assessment; Humans; Male; Medical sciences; Men; Metabolic diseases; Middle Aged; Miscellaneous; Mortality; Nutrition; Original Research; Prospective Studies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Risk; Risk factors; Smoking - adverse effects; Studies; Surveys and Questionnaires; Type 2 diabetes; Endocrinopathy; Consumption; Type 2 diabetes; Human; Nutrition; Metabolic diseases; Male; Cardiovascular disease; Risk; Coffee; Cause; Risk factor; Adult; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc08-2251

OBJECTIVE: Coffee consumption has been linked to detrimental acute metabolic and hemodynamic effects. We investigated coffee consumption in relation to risk of CVDs and mortality in diabetic men. RESEARCH DESIGN AND METHODS: We conducted a prospective cohort study including 3,497 diabetic men without CVD at baseline. RESULTS: After adjustment for age, smoking, and other cardiovascular risk factors, relative risks (RRs) were 0.88 (95% CI 0.50-1.57) for CVDs (P for trend = 0.29) and 0.80 (0.41-1.54) for all-cause mortality (P for trend = 0.45) for the consumption of greater-than-or-equal4 cups/day of caffeinated coffee compared with those for non-coffee drinkers. Stratification by smoking and duration of diabetes yielded similar results. RRs for caffeine intake for the highest compared with the lowest quintile were 1.02 (0.70-1.47; P for trend = 0.96) for CVDs and 0.96 (0.64-1.44; P for trend = 0.69) for mortality. CONCLUSIONS: These data indicate that regular coffee consumption is not associated with increased risk for CVDs or mortality in diabetic men.