The adaptive immunologic microenvironment in colorectal cancer : A novel perspective

Colorectal cancer is one of the most common malignancies, often presenting with a poor prognosis. To date, the anatomic extent of disease has been by far the most important prognostic factor. Recently, we obtained evidence that the type, density, and location of immune cells in colorectal cancer cou...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 67; no. 5; pp. 1883 - 1886
Main Authors:	GALON, Jérome, FRIDMAN, Wolf-Herman, PAGES, Franck
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-03-2007
Subjects:	Animals Antineoplastic agents Biological and medical sciences Biomarkers - analysis Colorectal Neoplasms - immunology Gastroenterology. Liver. Pancreas. Abdomen Humans Immunity, Cellular Medical sciences Models, Biological Pharmacology. Drug treatments Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Colonic disease Rectal disease Colorectal cancer Digestive diseases Intestinal disease Malignant tumor Microenvironment
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Summary:	Colorectal cancer is one of the most common malignancies, often presenting with a poor prognosis. To date, the anatomic extent of disease has been by far the most important prognostic factor. Recently, we obtained evidence that the type, density, and location of immune cells in colorectal cancer could provide a prognostic factor superior and independent to that of criteria related to the anatomic extent of the tumor. Here, we discuss the meaning and potential implications of this novel finding.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0008-5472 1538-7445
DOI:	10.1158/0008-5472.can-06-4806