Discovering MoRFs by trisecting intrinsically disordered protein sequence into terminals and middle regions

• Published in: BMC bioinformatics Vol. 19; no. Suppl 13; p. 378
• Main Authors: Sharma, Ronesh, Sharma, Alok, Patil, Ashwini, Tsunoda, Tatsuhiko
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04-02-2019; BioMed Central; BMC
• Subjects: Amino acids; Physiological aspects; Proteins; Fiji
• ISSN: 1471-2105; 1471-2105
• DOI: 10.1186/s12859-018-2396-7

Molecular Recognition Features (MoRFs) are short protein regions present in intrinsically disordered protein (IDPs) sequences. MoRFs interact with structured partner protein and upon interaction, they undergo a disorder-to-order transition to perform various biological functions. Analyses of MoRFs are important towards understanding their function.
Performance is reported using the MoRF dataset that has been previously used to compare the other existing MoRF predictors. The performance obtained in this study is equivalent to the benchmarked OPAL predictor, i.e., OPAL achieved AUC of 0.815, whereas the model in this study achieved AUC of 0.819 using TEST set.
Achieving comparable performance, the proposed method can be used as an alternative approach for MoRF prediction.