Comparative Evaluation of Endotoxin Activity Level and Various Biomarkers for Infection and Outcome of ICU-Admitted Patients

• Published in: Biomedicines Vol. 7; no. 3; p. 47
• Main Authors: Ikeda, Toshiaki, Kamohara, Hidenobu, Suda, Shingo, Nagura, Takeo, Tomino, Mikiko, Sugi, Masatoshi, Wajima, Zen'ichiro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29-06-2019; MDPI
• Subjects: Anticoagulants; Bacterial infections; Biomarkers; Blood; Blood culture; blood endotoxin; Consent; endotoxin activity assay (EAA); FDA approval; Gram-negative bacteria; Immunoassay; Infections; interleukin (IL)-6; Interleukin 6; Lactic acid; Monoclonal antibodies; Mortality; Neutrophils; Patients; presepsin; Procalcitonin; procalcitonin (PCT); Sepsis; Survival; Japan; Germany; presepsin; procalcitonin (PCT); blood endotoxin; endotoxin activity assay (EAA); interleukin (IL)-6; sepsis
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines7030047

Here, we concurrently measured the endotoxin activity (EA) level and levels of multiple biomarkers in patient blood obtained within 24 h after being admitted into the intensive care unit (ICU) and analyzed whether there were links between these markers and their associations with patient conditions and outcomes. The EA levels highly correlated with disease severity and patient survival, and showed a significant positive association with levels of lactate, procalcitonin, presepsin, and interleukin-6. Notably, the EA level was the marker that most highly correlated with the results of blood culture, and the presepsin level was the marker most highly correlated with the survival outcome at 28 days. Thus, the optimal biomarker should be selected based on whether it will be used to discriminate the presence of an infection or to predict survival.