Right atrial myxoma as the first manifestation of granulomatosis with polyangiitis, and a possible association with vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6): a case report and review of the literature

• Published in: European journal of medical research Vol. 27; no. 1; p. 4
• Main Authors: Corin, Joel, Carlsson, Amanda, Peters, Björn
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11-01-2022; BioMed Central; BMC
• Subjects: Anemia; Biopsy; Blood & organ donations; Case Report; Clinical Medicine; Creatinine; Cytokines; Female; Granulomatosis with Polyangiitis - complications; Granulomatosis with Polyangiitis - diagnosis; Granulomatosis with Polyangiitis - metabolism; Heart; Heart Atria; Heart Neoplasms - complications; Heart Neoplasms - diagnosis; Heart Neoplasms - metabolism; Humans; IL-6; Interleukin-6 - metabolism; Interleukins; Kidney - pathology; Kidneys; Klinisk medicin; Middle Aged; Myxoma; Myxoma - complications; Myxoma - diagnosis; Myxoma - metabolism; Patients; Proteins; Remission (Medicine); Risk factors; Sinusitis; Tomography; Tomography, X-Ray Computed; Ultrasonic imaging; Urine; Urologi och njurmedicin; Urology and Nephrology; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Vasculitis; VEGF; Wegener's granulomatosis; Myxoma; Case report; Vasculitis; VEGF; IL-6
• ISSN: 2047-783X; 0949-2321; 2047-783X
• DOI: 10.1186/s40001-022-00632-z

Granulomatosis with polyangiitis and myxomas are rare conditions previously described to co-exist. Cardiac masses are often presumed to be myxomas rather than lesions of granulomatosis with polyangiitis.
We present a review of the symptoms for the two diagnoses along with the first verified case.
Two possible risk factors for developing myxomas (VEGF and IL-6) are explored and discussed.