Median effective dose of esketamine for intranasal premedication in children with congenital heart disease

• Published in: BMC anesthesiology Vol. 23; no. 1; p. 129
• Main Authors: Huang, Jiajia, Liu, Daoqing, Bai, Jie, Gu, Hongbin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19-04-2023; BioMed Central; BMC
• Subjects: Administration, Intranasal; Adolescent; Adult; Anesthesia; Anxiety; Blood pressure; Cardiovascular disease; Child; Children; Clinical medicine; Complications and side effects; Computer simulation; Confidence intervals; Congenital diseases; Congenital heart disease; Dexmedetomidine; Drug dosages; Esketamine; Genetic disorders; Health aspects; Heart beat; Heart Defects, Congenital - surgery; Heart diseases; Heart rate; Humans; Hypnotics and Sedatives - therapeutic use; Hypoxia; Ketamine; Median effective dose (ED50); Medical personnel; Medical research; Medical societies; Methods; Nausea; Parenting; Patients; Pediatric cardiology; Pediatrics; Premedication; Preoperative sedation; Respiration; Success; Surgery; Vomiting; Young Adult; United States > US; Esketamine; Median effective dose (ED50); Congenital heart disease; Preoperative sedation
• ISSN: 1471-2253; 1471-2253
• DOI: 10.1186/s12871-023-02077-1

Esketamine is commonly used as a premedication for its sedation effect. However, the proper dosage for intranasal use in children with congenital heart disease (CHD) has not been determined. This study aimed to estimate the median effective dose (ED
) of esketamine for intranasal premedication in children with CHD.
Thirty-four children with CHD who needed premedication in March 2021 were enrolled. Intranasal esketamine was initiated at a dose of 1 mg/kg. Based on the outcome of sedation in the previous patient, the dose for the subsequent patient was either increased or reduced by 0.1 mg/kg, which was adjusted between each child. Successful sedation was defined as a Ramsay Sedation Scale score ≥ 3 and Parental Separation Anxiety Scale score ≤ 2. The required ED
of esketamine was calculated using the modified sequential method. Non-invasive blood pressure, heart rate, saturation of peripheral oxygen, sedation onset time, and adverse reactions were recorded at 5 min intervals after drug administration.
The 34 children enrolled had a mean age of 22.5 ± 16.4 (4-54) months and a mean weight of 11.2 ± 3.6 (5.5-20.5) kg; American Society of Anesthesiologists classification I-III. The ED
of intranasal S(+)-ketamine (esketamine) required for preoperative sedation in pediatric patients with CHD was 0.7 (95% confidence interval: 0.54-0.86) mg/kg, and the mean sedation onset time was 16.39 ± 7.24 min. No serious adverse events, such as respiratory distress, nausea, and vomiting were observed.
The ED
of intranasal esketamine was 0.7 mg/kg, which was safe and effective for preoperative sedation in pediatric patients with CHD.
The trial was registered in the Chinese Clinical Trial Registry Network (ChiCTR2100044551) on 24/03/2021.