Binding and entering: COVID finds a new home

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In t...

Full description

Saved in:

Bibliographic Details
Published in:	PLoS pathogens Vol. 17; no. 8; p. e1009857
Main Authors:	Vu, Michelle N, Menachery, Vineet D
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-08-2021 Public Library of Science (PLoS)
Subjects:	Angiotensin-Converting Enzyme 2 - metabolism Biology and life sciences Causes of Coronaviruses COVID-19 - metabolism COVID-19 - virology Epidemics Genetic aspects Health aspects Humans Medicine and health sciences Pearls Protein binding SARS-CoV-2 - pathogenicity SARS-CoV-2 - physiology Spike Glycoprotein, Coronavirus - metabolism United States Viral proteins Virulence (Microbiology) Virus Internalization United States
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-2 The authors have declared that no competing interests exist.
ISSN:	1553-7374 1553-7366 1553-7374
DOI:	10.1371/journal.ppat.1009857