Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients

• Published in: Archives of Dermatological Research Vol. 303; no. 6; pp. 451 - 455
• Main Authors: Nakajima, Hideki, Nakajima, Kimiko, Tarutani, Masahito, Morishige, Ryuji, Sano, Shigetoshi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-08-2011; Springer; Springer Nature B.V
• Subjects: Adipokines - blood; Biological and medical sciences; Cytokines - blood; Dermatology; Disease Progression; Gene Expression Regulation; Humans; Medical sciences; Medicine; Medicine & Public Health; Psoriasis - diagnosis; Psoriasis - immunology; Psoriasis - physiopathology; Psoriasis. Parapsoriasis. Lichen; Severity of Illness Index; Short Communication; Th17 Cells - immunology; Th17 Cells - metabolism; Th17 Cells - pathology; IL-22; IL-6; IL-21; HMW-adiponectin; Resistin; Adiponectin; Human; Skin disease; Psoriasis; Dermatology; Cytokine; Interleukin 6; Interleukin 21; Kinetics; Resisting
• ISSN: 0340-3696; 1432-069X
• DOI: 10.1007/s00403-011-1159-3

Psoriasis is associated with an increase of Th17 cytokines, such as IL-17, IL-22, IL-21, and TNF-α, which are produced by Th17 cells. Adipokines are peptide hormones or cytokines secreted from adipose tissues and involved in the pathogenesis of metabolic syndrome (MS). Psoriasis patients have a high prevalence of the MS. In this study, we investigated the statistics of circulating Th17-related cytokines and adipokines in psoriasis patients. Our study identified the significant elevation of serum IL-6, IL-21, IL-22, and resistin levels in psoriasis patients. Increased serum levels of IL-22 and adiponectin were positively correlated with Psoriasis Area and Severity Index (PASI). In contrast, serum high molecular weight adiponectin levels were decreased in psoriasis and negatively correlated with PASI.