Immunohistochemical determination of the site of hypotensive effects of glucagon-like peptide-2 in the rat brain

• Published in: Neuroscience Vol. 212; pp. 140 - 148
• Main Authors: Sasaki-Hamada, S, Okada, S, Ito, K, Iwai, T, Oka, J.-I
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 14-06-2012; Elsevier
• Subjects: Anesthetics - administration & dosage; Animals; area postrema; Biological and medical sciences; Blood pressure; Blood Pressure - drug effects; Blood Pressure - physiology; Brain; Brain Chemistry - drug effects; Brain Chemistry - physiology; Brain stem; c-Fos; c-Fos protein; Catecholamines; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Energy; Fos protein; Fundamental and applied biological sciences. Psychology; Gastrointestinal tract; GLP-2; Glucagon-like peptide 2; Glucagon-Like Peptide 2 - chemistry; Glucagon-Like Peptide 2 - physiology; heart rate; Hypotension; Hypotension - chemically induced; Hypotension - metabolism; immunohistochemistry; Male; Medulla oblongata; Nervous system; Neural Inhibition - drug effects; Neural Inhibition - physiology; Neurology; Neurons; Proto-Oncogene Proteins c-fos - chemistry; Proto-Oncogene Proteins c-fos - metabolism; Rats; Rats, Inbred WF; Solitary Nucleus - chemistry; Solitary Nucleus - drug effects; Solitary Nucleus - physiology; Solitary tract nucleus; sympathetic nerves; urethane; Vertebrates: nervous system and sense organs; dorsomedial hypothalamic nucleus; PVH; glucagon-like peptide-2; Fos-immunoreactivity; c-Fos; CNS; HR; NTS; locus coeruleus; area postrema; intravenous; A5; caudal ventrolateral medulla; c-fos protein; intracerebroventricular; A5 catecholamine cell group; immunohistochemistry; DMH; diaminobenzidine; blood pressure; heart rate; rostral ventrolateral medulla; RVLM; DAB; nucleus of the solitary tract; Fos-IR; CVLM; Fos; GAD; AP; central nervous system; glutamic acid decarboxylase; tyrosine hydroxylase; i.v; VMH; ventromedial hypothalamic nucleus; TH; paraventricular nucleus of the thalamus; LC; mean arterial blood pressure; i.c.v; GLP-2; MAP; Immunohistochemistry; Ependymal organ; Rat; fos Gene; Rodentia; Central nervous system; Glucagon-like peptide II; Encephalon; Heart rate; Vertebrata; Mammalia; Area postrema; Animal; Blood pressure; Hemodynamics; Protooncogene; Immediate early gene
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.03.032

Highlights ► GLP-2 (i.v. and i.c.v.) reduced mean arterial blood pressure in anesthetized rats. ► Administered GLP-2 induced Fos-immunoreactivity in the NTS and CVLM. ► It also induced Fos-immunoreactivity of GABAergic neurons in the NTS, CVLM and PVH. ► GLP-2 may inhibit sympathetic nerve activity resulting in hypotention.