Diversity and specificity of the mitogen-activated protein kinase phosphatase-1 functions

• Published in: Cellular and molecular life sciences : CMLS Vol. 70; no. 2; pp. 223 - 237
• Main Authors: Lawan, Ahmed, Shi, Hao, Gatzke, Florian, Bennett, Anton M.
• Format: Journal Article
• Language: English
• Published: Basel SP Birkhäuser Verlag Basel 01-01-2013; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cellular biology; Dephosphorylation; Dual Specificity Phosphatase 1 - genetics; Dual Specificity Phosphatase 1 - metabolism; Humans; Kinases; Life Sciences; Macrophages - immunology; MAP kinase; MAP kinase phosphatase; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases - metabolism; Molecular biology; Neoplasms - metabolism; Phosphorylation; Protein kinase; Proteins; Review; Signal Transduction; Threonine; MAP kinase phosphatase; MAP kinase; Phosphatases; Dephosphorylation; Knock-out mouse; Cell signaling
• ISSN: 1420-682X; 1420-9071
• DOI: 10.1007/s00018-012-1041-2

The balance of protein phosphorylation is achieved through the actions of a family of protein serine/threonine kinases called the mitogen-activated protein kinases (MAPKs). The propagation of MAPK signals is attenuated through the actions of the MAPK phosphatases (MKPs). The MKPs specifically inactivate the MAPKs by direct dephosphorylation. The archetypal MKP family member, MKP-1 has garnered much of the attention amongst its ten other MKP family members. Initially viewed to play a redundant role in the control of MAPK signaling, it is now clear that MKP-1 exerts profound regulatory functions on the immune, metabolic, musculoskeletal and nervous systems. This review focuses on the physiological functions of MKP-1 that have been revealed using mouse genetic approaches. The implications from studies using MKP-1-deficient mice to uncover the role of MKP-1 in disease will be discussed.