Translational precision medicine: an industry perspective

• Published in: Journal of translational medicine Vol. 19; no. 1; p. 245
• Main Authors: Hartl, Dominik, de Luca, Valeria, Kostikova, Anna, Laramie, Jason, Kennedy, Scott, Ferrero, Enrico, Siegel, Richard, Fink, Martin, Ahmed, Sohail, Millholland, John, Schuhmacher, Alexander, Hinder, Markus, Piali, Luca, Roth, Adrian
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05-06-2021; BioMed Central; BMC
• Subjects: Artificial Intelligence; Biomarkers; Clinical trials; Datasets; Disease; Drug development; Drug Discovery; Electronic health records; Genetics; Genomics; Humans; Methods; Modeling; Multi-omics; Pharmaceutical industry; Pharmaceutical research; Precision Medicine; Proteins; Proteomics; R&D; Research & development; Review; Technology application; Translation; Translational medicine; Translational research; Translational Research, Biomedical; Working groups; Switzerland; Precision medicine; Digital biomarkers; Translational medicine; Biomarkers; Drug development; Pharmaceutical industry; Artificial intelligence; Modeling; Companion diagnostics; Multi-omics
• ISSN: 1479-5876; 1479-5876
• DOI: 10.1186/s12967-021-02910-6

In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product and business model innovation, fundamentally changing the traditional approach of how drugs are discovered, developed and marketed. Critical to this transformation is the adoption of new technologies in the drug development process, catalyzing the transition from serendipity-driven to data-driven medicine. This paradigm shift comes with a need for both translation and precision, leading to a modern Translational Precision Medicine approach to drug discovery and development. Key components of Translational Precision Medicine are multi-omics profiling, digital biomarkers, model-based data integration, artificial intelligence, biomarker-guided trial designs and patient-centric companion diagnostics. In this review, we summarize and critically discuss the potential and challenges of Translational Precision Medicine from a cross-industry perspective.