Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial
[...]inotropes and vasoactive agents, often used in ICU treatments, can increase tissue injury and viral load via p38 MAPK activation [1, 2]. [...]a vicious cycle is established in viral sepsis leading to high mortality despite the current therapies. TH also appears to prevent herpes simplex virus i...
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| Published in: | Critical care (London, England) Vol. 24; no. 1; p. 209 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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BioMed Central Ltd
08-05-2020
BioMed Central BMC |
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| Abstract | [...]inotropes and vasoactive agents, often used in ICU treatments, can increase tissue injury and viral load via p38 MAPK activation [1, 2]. [...]a vicious cycle is established in viral sepsis leading to high mortality despite the current therapies. TH also appears to prevent herpes simplex virus infectivity and potentiate host defense by increasing natural killer cells (NK) and enhancing the stimulatory effect of interferon on NK cells [5]. Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis. |
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| AbstractList | [...]inotropes and vasoactive agents, often used in ICU treatments, can increase tissue injury and viral load via p38 MAPK activation [1, 2]. [...]a vicious cycle is established in viral sepsis leading to high mortality despite the current therapies. TH also appears to prevent herpes simplex virus infectivity and potentiate host defense by increasing natural killer cells (NK) and enhancing the stimulatory effect of interferon on NK cells [5]. Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis. |
| ArticleNumber | 209 |
| Audience | Academic |
| Author | Mourouzis, Iordanis Tseti, Ioulia Pantos, Constantinos |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32384906$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.4103/IJCIIS.IJCIIS_29_17 10.1177/0885066619892218 10.1007/s10741-014-9465-4 10.1161/CIRCRESAHA.108.191171 10.3109/07435800.2013.808208 |
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| References | 25501869 - Heart Fail Rev. 2015 May;20(3):273-82 2934_CR3 D Marchant (2934_CR2) 2009; 104 M Varedi (2934_CR5) 2014; 39 C Pantos (2934_CR1) 2015; 20 R Padhi (2934_CR4) 2018; 8 |
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| SubjectTerms | Betacoronavirus Clinical trials Coronavirus Infections Coronaviruses COVID-19 Critical care Critical Illness Herpes viruses Humans Hypoxia Illnesses Infection Intensive care Kinases Mortality Pandemics Pneumonia, Viral Research Letter SARS-CoV-2 Sepsis Septic shock Thyroid gland Thyroid Hormone Receptors alpha Thyroid hormones Triiodothyronine |
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| Title | Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial |
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