Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial

[...]inotropes and vasoactive agents, often used in ICU treatments, can increase tissue injury and viral load via p38 MAPK activation [1, 2]. [...]a vicious cycle is established in viral sepsis leading to high mortality despite the current therapies. TH also appears to prevent herpes simplex virus i...

Full description

Saved in:

Bibliographic Details
Published in:	Critical care (London, England) Vol. 24; no. 1; p. 209
Main Authors:	Pantos, Constantinos, Tseti, Ioulia, Mourouzis, Iordanis
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 08-05-2020 BioMed Central BMC
Subjects:	Betacoronavirus Clinical trials Coronavirus Infections Coronaviruses COVID-19 Critical care Critical Illness Herpes viruses Humans Hypoxia Illnesses Infection Intensive care Kinases Mortality Pandemics Pneumonia, Viral Research Letter SARS-CoV-2 Sepsis Septic shock Thyroid gland Thyroid Hormone Receptors alpha Thyroid hormones Triiodothyronine
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	[...]inotropes and vasoactive agents, often used in ICU treatments, can increase tissue injury and viral load via p38 MAPK activation [1, 2]. [...]a vicious cycle is established in viral sepsis leading to high mortality despite the current therapies. TH also appears to prevent herpes simplex virus infectivity and potentiate host defense by increasing natural killer cells (NK) and enhancing the stimulatory effect of interferon on NK cells [5]. Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis.
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 ObjectType-Commentary-2
ISSN:	1364-8535 1466-609X 1364-8535 1366-609X
DOI:	10.1186/s13054-020-02934-2