Glycosphingolipids as receptors for non-enveloped viruses

Glycosphingolipids as receptors for non-enveloped viruses

Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate stru...

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Bibliographic Details
Published in:Viruses Vol. 2; no. 4; pp. 1011 - 1049
Main Authors: Taube, Stefan, Jiang, Mengxi, Wobus, Christiane E
Format: Journal Article Book Review
Language:English
Published: Switzerland MDPI AG 01-04-2010
Molecular Diversity Preservation International (MDPI)
Subjects:
calicivirus
glycosphingolipid
non-enveloped virus
parvovirus
polyomavirus
receptor
Review
rotavirus
polyomavirus
receptor
rotavirus
non-enveloped virus
calicivirus
glycosphingolipid
parvovirus
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Summary:Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate structures displayed on a specific cell surface for attachment during infection. For some viruses, such as the polyomaviruses, binding to gangliosides determines the internalization pathway into cells. For others, the interaction between microbe and carbohydrate can be a critical determinant for host susceptibility. In this review, we summarize the role of glycosphingolipids as receptors for members of the non-enveloped calici-, rota-, polyoma- and parvovirus families.
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These authors contributed equally to the work.
ISSN:1999-4915
1999-4915
DOI:10.3390/v2041011