Rationale and guidance for strengthening infection prevention and control measures and antimicrobial stewardship programs in Bangladesh: a study protocol

• Published in: BMC health services research Vol. 22; no. 1; p. 1239
• Main Authors: Harun, Md Golam Dostogir, Anwar, Md Mahabub Ul, Sumon, Shariful Amin, Hassan, Md Zakiul, Mohona, Tahrima Mohsin, Rahman, Aninda, Abdullah, Syed Abul Hassan Md, Islam, Md Saiful, Kaydos-Daniels, S Cornelia, Styczynski, Ashley R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 07-10-2022; BioMed Central; BMC
• Subjects: Anti-Bacterial Agents - therapeutic use; Antibiotics; Antimicrobial agents; Antimicrobial resistance; Antimicrobial Stewardship; Bangladesh; Care and treatment; Collaboration; Committees; Cross infection; Cross Infection - drug therapy; Cross Infection - prevention & control; Disease control; Dosage and administration; Drug resistance; Drug resistance in microorganisms; Health care; Health facilities; Health services; Healthcare quality improvement; Hospital-acquired infections; Hospitalization; Hospitals; Humans; Infection control; Infection Control - methods; Infection prevention and control; Methods; Nosocomial infections; Patient outcomes; Patient safety; Pneumonia; Prevention; Quality improvement; Staphylococcus infections; Study Protocol; Surveillance; Tertiary hospital; Bangladesh; Antimicrobial stewardship; Antimicrobial resistance; Hospital-acquired infections; Infection prevention and control; Healthcare quality improvement; Tertiary hospital
• ISSN: 1472-6963; 1472-6963
• DOI: 10.1186/s12913-022-08603-0

Hospital-acquired infections (HAIs) and antimicrobial resistance (AMR) are major global health challenges. Drug-resistant infectious diseases continue to rise in developing countries, driven by shortfalls in infection control measures, antibiotic misuse, and scarcity of reliable diagnostics. These escalating global challenges have highlighted the importance of strengthening fundamental infection prevention and control (IPC) measures and implementing effective antimicrobial stewardship programs (ASP). This study aims to present a framework for enhancing IPC measures and ASP efforts to reduce the HAI and AMR burden in Bangladesh.
This implementation approach will employ a mixed-methods strategy, combining both quantitative and qualitative data from 12 tertiary hospitals in Bangladesh. A baseline assessment will be conducted using the Infection Prevention and Control Assessment Framework (IPCAF) developed by the WHO. We will record IPC practices through direct observations of hand hygiene, personal protective equipment (PPE) utilization, and hospital ward IPC infrastructure. Additionally, data on healthcare providers' knowledge, attitudes, and practices regarding IPC and antibiotic prescribing will be collected using both structured questionnaires and qualitative interviews. We will also assist the hospital leadership with establishing and/or strengthening IPC and ASP committees. Based on baseline assessments of each healthcare facility, tailored interventions and quality improvement projects will be designed and implemented. An end-line assessment will also be conducted after 12 months of intervention using the same assessment tools. The findings will be compared with the baseline to determine changes in IPC and antibiotic stewardship practices.
Comprehensive assessments of healthcare facilities in low-resource settings are crucial for strengthening IPC measures and ASP activities,. This approach to assessing existing IPC and ASP activities will provide policy-relevant data for addressing current shortfalls. Moreover, this framework proposes identifying institutionally-tailored solutions, which will ensure that response activities are appropriately contextualized, aligned with stakeholder priorities, and offer sustainable solutions.
Findings from this study can guide the design and implementation of feasible and sustainable interventions in resource-constrained healthcare settings to address gaps in existing IPC and ASP activities. Therefore, this protocol will be applicable across a broad range of settings to improve IPC and ASP and reduce the burden of hospital-acquired infections and AMR.