Chemistry and Biological Activities of 1,2,4-Triazolethiones-Antiviral and Anti-Infective Drugs

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 13; p. 3036
• Main Authors: Aly, Ashraf A, A Hassan, Alaa, Makhlouf, Maysa M, Bräse, Stefan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03-07-2020; MDPI
• Subjects: 1,2,4-triazole ring; Acids; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Anticonvulsants; Antiinfectives and antibacterials; Antimicrobial agents; Antiviral agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Bacteria - drug effects; Biological activity; Cancer; Drug resistance; Enzymes; Fungi - drug effects; Heterocyclic compounds; Humans; Infections; Microorganisms; Natural products; Pharmaceuticals; Potassium; reactions; Review; Sulfur; synthesis; Triazoles; Triazoles - chemistry; Triazoles - pharmacology; Tropical diseases; Tuberculosis; Viral infections; Viruses - drug effects; West Nile virus; synthesis; reactions; biological activity; 1,2,4-triazole ring
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25133036

Mercapto-substituted 1,2,4-triazoles are very interesting compounds as they play an important role in chemopreventive and chemotherapeutic effects on cancer. In recent decades, literature has been enriched with sulfur- and nitrogen-containing heterocycles which are used as a basic nucleus of different heterocyclic compounds with various biological applications in medicine and also occupy a huge part of natural products. Therefore, we shed, herein, more light on the synthesis of this interesting class and its application as a biologically active moiety. They might also be suitable as antiviral and anti-infective drugs.