ICU bereaved surrogates' comorbid psychological-distress states and their associations with prolonged grief disorder

• Published in: Critical care (London, England) Vol. 26; no. 1; p. 102
• Main Authors: Wen, Fur-Hsing, Chou, Wen-Chi, Huang, Chung-Chi, Hu, Tsung-Hui, Chiang, Ming Chu, Chuang, Li-Pang, Tang, Siew Tzuh
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11-04-2022; BioMed Central; BMC
• Subjects: Anxiety; Bereavement; Comorbidity; Complications and side effects; Critical care; Critically ill; Data collection; Decision making; Depression; Depression - psychology; Depression, Mental; Diagnosis; Family; Grief; Health aspects; Humans; Intensive care; Intensive Care Units; Mental depression; Patients; Post traumatic stress disorder; Probability; Prolonged Grief Disorder; Psychological aspects; Psychological Distress; Psychological research; Risk factors; Social aspects; Stress Disorders, Post-Traumatic - complications; Stress Disorders, Post-Traumatic - epidemiology; Stress Disorders, Post-Traumatic - psychology; Taiwan; Bereavement; ICU care; End-of-life care; Psychological distress; Post-traumatic stress disorder; Depression; Anxiety; Prolonged grief disorder
• ISSN: 1364-8535; 1466-609X; 1364-8535; 1366-609X
• DOI: 10.1186/s13054-022-03981-7

Bereaved ICU family surrogates' psychological distress, e.g., anxiety, depression, and post-traumatic stress disorder (PTSD), is usually examined independently, despite the well-recognized comorbidity of these symptoms. Furthermore, the few studies exploring impact of psychological distress on development of prolonged grief disorder (PGD) did not consider the dynamic impact of symptom evolution. We identified surrogates' distinct patterns/states of comorbid psychological distress and their evolution over the first 3 months of bereavement and evaluated their associations with PGD at 6-month postloss.
A longitudinal observational study was conducted on 319 bereaved surrogates. Symptoms of anxiety, depression, PTSD, and PGD were measured by the anxiety and depression subscales of the Hospital Anxiety and Depression Scale, Impact of Event Scale-Revised scale, and the PGD-13, respectively. Distinct psychological-distress states and their evolution were examined by latent transition analysis. Association between psychological-distress states and PGD symptoms was examined by logistic regression.
Three distinct comorbid psychological-distress states (prevalence) were initially identified: no distress (56.3%), severe-depressive/borderline-anxiety distress (30.5%), and severe-anxiety/depressive/PTSD distress (13.3%). Except for those in the stable no-distress state, surrogates tended to regress to states of less psychological distress at the subsequent assessment. The proportion of participants in each psychological-distress state changed to no distress (76.8%), severe-depressive/borderline-anxiety distress (18.6%), and severe-anxiety/depressive/PTSD distress (4.6%) at 3-month postloss. Surrogates in the severe-depressive/borderline-anxiety distress and severe-anxiety/depressive/PTSD-distress state at 3-month postloss were more likely to develop PGD at 6-month postloss (OR [95%] = 14.58 [1.48, 143.54] and 104.50 [10.45, 1044.66], respectively).
A minority of family surrogates of ICU decedents suffered comorbid severe-depressive/borderline-anxiety distress and severe-anxiety/depressive/PTSD symptoms during early bereavement, but they were more likely to progress into PGD at 6-month postloss.