Neuroprotective and Antiapoptotic Potential of Trigonelline in a Striatal 6-Hydroxydopamine Rat Model of Parkinson’s Disease

• Published in: Neurophysiology (New York) Vol. 48; no. 3; pp. 176 - 183
• Main Authors: Mirzaie, M., Khalili, M., Kiasalari, Z., Roghani, M.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2016; Springer; Springer Nature B.V
• Subjects: 6-Hydroxydopamine; Apoptosis; Biomedical and Life Sciences; Biomedicine; Glutathione; Malondialdehyde; Movement disorders; Neostriatum; Neurobiology; Neurodegenerative diseases; Neuroprotection; Neurosciences; Neurotoxicity; Nitrites; Oxidative stress; Parkinson's disease; Rodents; Rotational behavior; Substantia nigra; Toxicity; apoptosis; 6-hydroxydopamine; trigonelline; Parkinson’s disease; oxidative stress
• ISSN: 0090-2977; 1573-9007
• DOI: 10.1007/s11062-016-9586-6

Considering neuroprotective and antioxidant effects of trigonelline, our study was undertaken to evaluate its protective effect in a 6-hydroxydopamine-induced model of Parkinson’s disease (PD) in rats. Unilateral intrastriatal 6-OHDA-lesioned rats were pretreated with trigonelline at doses of 50 and 100 mg/kg. Significant rotational behavior, a significant reduction in the number of Nissl-stained neurons on the left side of the
substantia nigra pars compacta
(SNC), increased apoptosis, enhanced levels of malondialdehyde (MDA) and nitrite, and a lower level of glutathione (GSH) were observed in 6-OHDA-lesioned rats. Trigonelline at a dose of 100 mg/kg significantly reduced rotations, prevented reduction of SNC neurons, prevented apoptosis, and restored the MDA level. These results suggest that pre-lesion trigonelline treatment exerts dose-dependent neuroprotective and antiapoptotic effects under conditions of 6-OHDA toxicity and may be, henceforth, advantageous for the management of early PD.