Fingerprint–efficacy study of Radix Aconiti Lateralis Preparata (Fuzi) in quality control of Chinese herbal medicine

• Published in: Journal of thermal analysis and calorimetry Vol. 118; no. 3; pp. 1763 - 1772
• Main Authors: Zhu, Yun, Zheng, Quanfu, Sun, Zhiyong, Chen, Zhe, Zhao, Yanling, Wang, Zhongxia, Yang, Huiyin, Li, Jianyu, Li, Yonggang, Xiao, Xiaohe
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01-12-2014; Springer
• Subjects: Analytical Chemistry; Calorimetry; Chemistry; Chemistry and Materials Science; Correlation analysis; Fingerprints; Herbal medicine; Inorganic Chemistry; Maximum power; Measurement Science and Instrumentation; Medicine, Botanic; Medicine, Chinese; Medicine, Herbal; Mitochondria; Mitochondrial DNA; Physical Chemistry; Polymer Sciences; Principal component analysis; Quality control; Chemical fingerprint; Promoting metabolic effect; Radix; Fingerprint–efficacy; Lateralis Preparata; Quality control; )
• ISSN: 1388-6150; 1588-2926; 1572-8943
• DOI: 10.1007/s10973-014-4072-0

For quality control of Chinese herbal medicine (CHM), an attempt on fingerprint–efficacy study of Radix
Aconiti
Lateralis Preparata (
Fuzi
) was developed in this paper. The fingerprints of
Fuzi
from various sources were determined by UPLC and hierarchical clustering analysis. Some quantitative thermo-kinetic parameters such as the heat-flow maximum power (
P
max
) and its time corresponding to
t
max
, which obtained from the thermogenic curves of mitochondria metabolic activity affected by
Fuzi
were analyzed using principal component analysis. The fingerprint–efficacy relationship of chemical fingerprint and promoting effect of
Fuzi
were established using canonical correlation analysis. Our results showed that the sources and places of production of
Fuzi
had some significant influence on the chemical fingerprints and promoting metabolic effects of this CHM. Fingerprint–efficacy study provided a powerful way and some references for the quality control of
Fuzi
and other CHMs.