Designing Click One-Pot Synthesis and Antidiabetic Studies of 1,2,3-Triazole Derivatives

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 7; p. 3104
• Main Authors: Shafique, Kainat, Farrukh, Aftab, Mahmood Ali, Tariq, Qasim, Sumera, Jafri, Laila, Abd-Rabboh, Hisham S M, Al-Anazy, Murefah Mana, Kalsoom, Saima
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30-03-2023; MDPI
• Subjects: Acarbose; alpha-Amylases - metabolism; alpha-Glucosidases - metabolism; Amino acids; Amylases; antidiabetic assay molecular docking; Antidiabetics; Care and treatment; Datasets; Design; Diabetes; Diabetes mellitus; Drugs; Glucosidase; Glycoside Hydrolase Inhibitors - chemistry; Hypoglycemic agents; Hypoglycemic Agents - chemistry; Insulin; Ligands; Metabolism; Molecular docking; Molecular Docking Simulation; Molecular Structure; Nitrogen; Pharmacokinetics; Proteins; Spectroscopy, Fourier Transform Infrared; Spectrum analysis; Structure-Activity Relationship; Testing; triazole derivatives; Triazoles; Triazoles - chemistry; Triazoles - pharmacology; α-Amylase; α-Glucosidase; Pakistan; antidiabetic assay molecular docking; diabetes mellitus; triazole derivatives
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28073104

In the present study, a new series of 1,2,3-triazole derivatives was synthesized via a click one-pot reaction. The synthesized compounds were found to be active during molecular docking studies against targeted protein 1T69 by using the Molecular Operating Environment (MOE) software. The designed and synthesized compounds were characterized by using FT-IR,
H-NMR and LC-MS spectra. The synthesized triazole moieties were further screened for their α-amylase and α-glucosidase inhibitory activities. The preliminary activity analysis revealed that all the compounds showed good inhibition activity, ranging from moderate to high depending upon their structures and concentrations and compared to the standard drug acarbose. Both in silico and in vitro analysis indicated that the synthesized triazole molecules are potent for DM type-II. Out of all the compounds, compound K-1 showed the maximum antidiabetic activity with 87.01% and 99.17% inhibition at 800 µg/mL in the α-amylase and α-glucosidase inhibition assays, respectively. Therefore these triazoles may be further used as promising molecules for development of antidiabetic compounds.