The secondary metabolites of rare actinomycetes: chemistry and bioactivity
Actinomycetes are outstanding and fascinating sources of potent bioactive compounds, particularly antibiotics. In recent years, rare actinomycetes have had an increasingly important position in the discovery of antibacterial compounds, especially Micromonospora , Actinomadura and Amycolatopsis . Foc...
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| Published in: | RSC advances Vol. 9; no. 38; pp. 21964 - 21988 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Royal Society of Chemistry
16-07-2019
The Royal Society of Chemistry |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Actinomycetes are outstanding and fascinating sources of potent bioactive compounds, particularly antibiotics. In recent years, rare actinomycetes have had an increasingly important position in the discovery of antibacterial compounds, especially
Micromonospora
,
Actinomadura
and
Amycolatopsis
. Focusing on the period from 2008 to 2018, we herein summarize the structures and bioactivities of secondary metabolites from rare actinomycetes, involving 21 genera.
A detailed introduction to the structures and bioactivities of secondary metabolites from rare actinomycetes is made. |
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| Bibliography: | Wei-dong Zhang is currently vice-dean of the School of Pharmacy/chief director of the Department of Phytochemistry and Modern Research Center for Traditional Chinese Medicine in the Second Military Medical University of China. He studied Medicinal Chemistry at the Second Military Medical University between 1987 and 1994, leading to BSc and MSc degrees, and pursued further education at Shanghai Institute of Pharmaceutical Industry, where he acquired a PhD degree in 2002. His major achievements are in the fields of bioactive natural product discovery for therapeutic applications, the chemical biology of natural products, and innovative drug discovery from TCM. Ting Ding obtained her bachelor's degree in pharmaceutical engineering at Southeast University in 2017. In the same year, she started her postgraduate career at China State Institute of Pharmaceutical Industry. Now she focuses on the secondary metabolites of rare actinomycetes and fungi coming from soil. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 2046-2069 2046-2069 |
| DOI: | 10.1039/c9ra03579f |