A Review of Biologically Active Oxime Ethers

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 13; p. 5041
• Main Authors: Kosmalski, Tomasz, Kupczyk, Daria, Baumgart, Szymon, Paprocka, Renata, Studzińska, Renata
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28-06-2023; MDPI
• Subjects: Anesthetics, General; Anti-Bacterial Agents - pharmacology; anticancer activity; Antidepressants; antidepressive activity; Antifungal agents; antimicrobial activity; Biological activity; Drugs; Ethers; Ethers - chemistry; Fluvoxamine; Fungicides; Fungicides, Industrial - pharmacology; oxime ethers; Oximes - chemistry; Oximes - pharmacology; Review; Reviews; siponimod; Structure-Activity Relationship; Yeast; Niger; ridogrel; oxiconazole; anticancer activity; antidepressive activity; antimicrobial activity; fluvoxamine; oxime ethers; siponimod
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules28135041

Oxime ethers are a class of compounds containing the >C=N-O-R moiety. The presence of this moiety affects the biological activity of the compounds. In this review, the structures of oxime ethers with specific biological activity have been collected and presented, and bactericidal, fungicidal, antidepressant, anticancer and herbicidal activities, among others, are described. The review includes both those substances that are currently used as drugs (e.g., fluvoxamine, mayzent, ridogrel, oxiconazole), as well as non-drug structures for which various biological activity studies have been conducted. To the best of our knowledge, this is the first review of the biological activity of compounds containing such a moiety. The authors hope that this review will inspire scientists to take a greater interest in this group of compounds, as it constitutes an interesting research area.