Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte...

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Bibliographic Details
Published in:	Chemical Society reviews Vol. 49; no. 15; p. 5110
Main Authors:	Wu, Luling, Huang, Chusen, Emery, Ben P, Sedgwick, Adam C, Bull, Steven D, He, Xiao-Peng, Tian, He, Yoon, Juyoung, Sessler, Jonathan L, James, Tony D
Format:	Journal Article
Language:	English
Published:	England 07-08-2020
Subjects:	Animals Biological Transport Biomedical Enhancement Biosensing Techniques Cell Line Cellular Microenvironment Fluorescence Resonance Energy Transfer - methods Humans Inorganic Chemicals - analysis Ions - analysis Membrane Potential, Mitochondrial Microscopy, Fluorescence Neoplasms - diagnostic imaging Optical Imaging Spectrometry, Fluorescence Surface Properties
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Summary:	In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes. The advantages of FRET-based fluorescent probes include: a large Stokes shift, ratiometric sensing and dual/multi-analyte responsive systems. We discuss the underlying energy donor-acceptor dye combinations and emphasise their applications for the detection or imaging of cations, anions, small neutral molecules, biomacromolecules, cellular microenvionments and dual/multi-analyte responsive systems.
ISSN:	1460-4744
DOI:	10.1039/c9cs00318e