Potential Immunoregulatory Mechanism of Plant Saponins: A Review

• Published in: Molecules (Basel, Switzerland) Vol. 29; no. 1; p. 113
• Main Authors: Shen, Liuhong, Luo, Hao, Fan, Lei, Tian, Xinyu, Tang, Anguo, Wu, Xiaofeng, Dong, Ke, Su, Zhetong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23-12-2023; MDPI
• Subjects: Antibodies; Antigens; B cells; Cytokines; Cytotoxicity; Immune response; Immune system; Immunity; immunomodulators; Lymphocytes; phytochemicals; plant saponins; Review; Saponins; Spleen; Steroids; Tumor necrosis factor-TNF; Vaccines; Canada; China; plant saponins; immunomodulators; phytochemicals; immunity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules29010113

Saponins are extracted from different parts of plants such as seeds, roots, stems, and leaves and have a variety of biological activities including immunomodulatory, anti-inflammatory effects, and hypoglycemic properties. They demonstrate inherent low immunogenicity and possess the capacity to effectively regulate both the innate and adaptive immune responses. Plant saponins can promote the growth and development of the body's immune organs through a variety of signaling pathways, regulate the activity of a variety of immune cells, and increase the secretion of immune-related cytokines and antigen-specific antibodies, thereby exerting the role of immune activity. However, the chemical structure of plant saponins determines its certain hemolytic and cytotoxicity. With the development of science and technology, these disadvantages can be avoided or reduced by certain technical means. In recent years, there has been a significant surge in interest surrounding the investigation of plant saponins as immunomodulators. Consequently, the objective of this review is to thoroughly examine the immunomodulatory properties of plant saponins and elucidate their potential mechanisms, with the intention of offering a valuable point of reference for subsequent research and advancement within this domain.