Mast cell activation — a receptor-independent mode of substance P action?

• Published in: FEBS letters Vol. 221; no. 2; pp. 236 - 240
• Main Authors: Repke, H., Bienert, M.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 14-09-1987; Elsevier
• Subjects: Ahx, 6-aminohexanoic acid; Animals; Biological and medical sciences; C12H25, dodecyl; C17H35 stearyl; Cpa, p-chlorophenylalanine; Dhp, Δ3,4-dehydroproline; Fundamental and applied biological sciences. Psychology; Histamine release; Histamine Release - drug effects; Inflammation; Male; Mast cell; Mast Cells - drug effects; Mast Cells - metabolism; Molecular and cellular biology; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter - drug effects; SP, substance P; Structure-Activity Relationship; Substance P; Substance P - pharmacology; Ahx, 6-aminohexanoic acid; Substance P; SP, substance P; Mast cell; C 17H 35 stearyl; Histamine release; Cpa, p-chlorophenylalanine; C 12H 25, dodecyl; Dhp, Δ 3,4-dehydroproline; Histamine; Vertebrata; Mammalia; Rat; Rodentia; Activation; Neuropeptide; Release; Peritoneum
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/0014-5793(87)80932-8

Substance P is a representative of a group of amphiphilic neuropeptides which act as mast cell secretagogues. Our experiments with some new substance P derivatives suggest that these effects are dependent on two structural elements: (i) a hydrophobic chain which is not essentially a peptide, and (ii) a hydrophilic part with two positively charged amino acids. The mast cell triggering effect is unlikely to be mediated by a selective substance P receptor, but has strong similarities to the mode of action of polycations.