Ultrasound analysis of gray‐scale median value of carotid plaques is a useful reference index for cerebro‐cardiovascular events in patients with type 2 diabetes

• Published in: Journal of diabetes investigation Vol. 6; no. 1; pp. 91 - 97
• Main Authors: Ariyoshi, Kyoko, Okuya, Shigeru, Kunitsugu, Ichiro, Matsunaga, Kimie, Nagao, Yuko, Nomiyama, Ryuta, Takeda, Komei, Tanizawa, Yukio
• Format: Journal Article
• Language: English
• Published: Japan John Wiley & Sons, Inc 01-01-2015; BlackWell Publishing Ltd
• Subjects: Angina pectoris; Arachidonic acid; Arteriosclerosis; Atherosclerosis; Blood platelets; Cardiovascular diseases; Carotid arteries; Carotid artery; Cholesterol; Chromatography; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Eicosapentaenoic acid; Fatty acids; Heart attacks; Laboratories; Lipids; Patients; Plaque echogenicity; Plaques; Platelet aggregation; Risk factors; Studies; Ultrasonic imaging; Ultrasound; Japan; Eicosapentaenoic acid; Atherosclerosis; Plaque echogenicity
• ISSN: 2040-1116; 2040-1124
• DOI: 10.1111/jdi.12242

Aims/Introduction
Measurements of plaque echogenicity, the gray‐scale median (GSM), were shown to correlate inversely with risk factors for cerebro‐cardiovascular disease (CVD). The eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio is a potential predictor of CVD risk. In the present study, we assessed the usefulness of carotid plaque GSM values and EPA/AA ratios in atherosclerotic diabetics.
Materials and Methods
A total of 84 type 2 diabetics with carotid artery plaques were enrolled. On admission, platelet aggregation and lipid profiles, including EPA and AA, were examined. Using ultrasound, mean intima media thickness and plaque score were measured in carotid arteries. Plaque echogenicity was evaluated using computer‐assisted quantification of GSM. The patients were then further observed for approximately 3 years.
Results
Gray‐scale median was found to be a good marker of CVD events. On multivariate logistic regression analysis, GSM <32 and plaque score ≥5 were significantly associated with past history and onset of CVD during the follow‐up period, the odds ratios being 7.730 (P = 0.014) and 4.601 (P = 0.046), respectively. EPA/AA showed a significant correlation with GSM (P = 0.012) and high‐density lipoprotein cholesterol (P = 0.039), and an inverse correlation with platelet aggregation (P = 0.046) and triglyceride (P = 0.020). Although most patients with CVD had both low GSM and low EPA/AA values, an association of EPA/AA with CVD events could not be statistically confirmed.
Conclusions
The present results suggest the GSM value to be useful as a reference index for CVD events in high‐risk atherosclerotic diabetics. Associations of the EPA/AA ratio with known CVD risk factors warrant a larger and more extensive study to show the usefulness of this parameter.