The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016

• Published in: BMC musculoskeletal disorders Vol. 20; no. 1; p. 78
• Main Authors: Wang, Xi, Ning, Yujie, Liu, Amin, Qi, Xin, Liu, Meidan, Zhang, Pan, Guo, Xiong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14-02-2019; BioMed Central; BMC
• Subjects: Correlation analysis; Criminal investigation; Database industry; Detective fiction; Diagnosis; Disease prevention; Estimates; Health care; Health surveillance; Infrastructure (Economics); Kashin-Beck disease; Linear free energy relationship; Meta-analysis; Musculoskeletal diseases; Preventive medicine; Public health; Reviews; Risk factors; Selenium; Studies; Systematic review; Technology; X-ray detective rate; X-rays; Tibet; China; Correlation analysis; X-ray detective rate; Kashin-Beck disease; Meta-analysis
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-019-2461-z

Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. However, quantitative syntheses of X-ray detective rate studies for KBD are rare. We performed an initial systematic review and meta-analysis to assess the X-ray detective rate of KBD in China.
For this systematic review and meta-analysis, we searched five databases (PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), WanFang Data and the China Science and Technology Journal Database (VIP))using a comprehensive search strategy to identify studies of KBD X-ray detective rate in China that were published from database inception to January 13, 2018. The X-ray detective rate of KBD was determined via an analysis of published studies using a random effect meta-analysis with the proportions approach. Subgroup analysis and meta-regression were used to explore heterogeneity, and study quality was assessed using the risk of bias tool.
A total of 53 studies involving 14,039 samples with X-ray detective rate in 163,340 observations in total were included in this meta-analysis. These studies were geographically diverse (3 endemic areas). The pooled overall X-ray detective rate for KBD was 11% (95%CI,8-15%;Z = 13.14; p < 0.001). The pooled X-ray detective rate estimates were 11% (95%CI, 6-17%; Z = 7.06; p < 0.001) for northeast endemic areas, 13% (95%CI, 7-20%; Z = 7.45; p < 0.001) for northwest endemic areas, and 8% (95%CI, 5-12%; Z = 7.90; p < 0.001) for southwest endemic areas. There was a significant relationship between the survey year and the X-ray detective rate of KBD.
Our systematic review found that the summary estimate of the X-ray detective rate of KBD was 11% and, that KBD X-ray positive rate ranged from 8.00 to 15.00% depending on the study. Further research is required to identify effective strategies for preventing and treating KBD.