The clinical prognostic significance of hs-cTnT elevation in patients with acute ischemic stroke

• Published in: BMC neurology Vol. 18; no. 1; p. 118
• Main Authors: He, Lanying, Wang, Jian, Dong, Weiwei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20-08-2018; BioMed Central; BMC
• Subjects: Acute ischemic stroke; Aged; Biomarkers - blood; Brain Ischemia - blood; Brain Ischemia - diagnosis; Brain Ischemia - epidemiology; Calcium-binding protein; Cardiac arrhythmia; Cardiovascular disease; CAT scans; Cohort Studies; Confidence intervals; Coronary artery disease; Death; Heart damage; Heart diseases; Heart failure; Hs-cTnT,electrocardiographic abnormality; Humans; Insular stroke; Ischemia; Medical imaging; Middle Aged; NMR; Nuclear magnetic resonance; Odds Ratio; Patient outcomes; Patients; Prognosis; Risk factors; Stroke; Stroke - blood; Stroke - diagnosis; Stroke - epidemiology; Studies; Troponin; Troponin T - blood; Insular stroke; Hs-cTnT,electrocardiographic abnormality; Acute ischemic stroke; Heart damage
• ISSN: 1471-2377; 1471-2377
• DOI: 10.1186/s12883-018-1121-5

Cardiac autonomic dysfunction caused by ischemic stroke might lead to an adverse outcome. Elevated high sensitivity cardiac troponin (hs-cTnT) is a marker of cardiac disease, it can elevate in acute stroke patients. The aim of the present study was to investigate association between serum hs-cTnT with prognosis among patients with acute ischemic stroke.
Five hundred and sixteen patients (mean age 66.19 ± 10.11) with acute ischemic stroke underwent a comprehensive clinical investigation and serum hs-cTnT activity test. All patients were followed up for 3 months. The prognosis was death or major disability (modified Rankin Scale score ≥ 3) at 3 months after acute ischemic stroke.
22.87% (118/516) of patients had serum hs-cTnT elevation (≥14 ng/l). Compared with normal hs-TnT group, the incidence of insular stroke (adjusted odds ratio, 2.84; 95% confidence interval, 1.48-4.17; P = 0.001) were more likely in patients with hs-cTnT elevation. In fully adjusted models, there was an association between serum hs-cTnT elevation and death (adjusted odds ratio, 3.14; 95% confidence interval, 1.16-8.49; P = 0.02) and major disability(adjusted odds ratio, 2.07; 95% confidence interval, 1.04-4.51; P = 0.04), and composite outcome(adjusted odds ratio,2.22;95% confidence interval,1.10-4.48; P = 0.03).
Higher levels of serum hs-cTnT were independently associated with increased risk of death or major disability after stroke onset, suggesting that serum hs-cTnT may have prognostic value in poor outcomes of ischemic stroke.