Plasma Thrombin-activatable Fibrinolysis Inhibitor Levels Correlate with the Disease Activity of Ulcerative Colitis

• Published in: Internal Medicine Vol. 55; no. 14; pp. 1831 - 1836
• Main Authors: Beyazit, Yavuz, Sayilir, Abdurrahim, Tanoglu, Alpaslan, Kekilli, Murat, Kocak, Erdem, Ekiz, Fuat, Tas, Adnan
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01-01-2016
• Subjects: Adult; Biomarkers; Carboxypeptidase B2 - blood; Carboxypeptidase B2 - immunology; Colitis, Ulcerative - blood; Colitis, Ulcerative - metabolism; Enzyme-Linked Immunosorbent Assay; Female; Humans; Inflammation - blood; Inflammation - metabolism; Inflammation Mediators - metabolism; Male; Middle Aged; Nuclear polyhedrosis virus; plasma thrombin-activatable fibrinolysis inhibitor; treatment; ulcerative colitis
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.55.6473

Objective Patients with ulcerative colitis (UC) are at an increased risk for thromboembolic events, particularly in patients with extensive and active disease. To date, a few studies have been published on the role of thrombin-activatable fibrinolysis inhibitor (TAFI) in UC. However, there are no reports in the literature investigating the effect of UC treatment on plasma TAFI levels. Methods The plasma TAFI antigen levels were quantitatively determined using ELISA kits for 20 UC patients at activation and remission, along with 17 healthy controls. The association between the TAFI levels and inflammatory markers was assessed to determine UC activation. To predict and determine the activation of UC, the Truelove-Witts index and the endoscopic activation index (EAI) were used for each subject. Results The plasma TAFI levels were higher in UC patients at activation of the disease compared with the remission state and in healthy controls. Spearman's correlation analyses revealed that the WBC (r: 0.586, p<0.001), hsCRP (r: 0.593, p<0.001) and EAI (r: 0.721, p<0.001) were significantly correlated with the TAFI levels. The overall accuracy of TAFI in determining UC activation was 82.5% with a sensitivity, specificity, NPV and PPV of 80%, 85%, 81% and 84.2%, respectively (cut-off value: 156.2% and AUC: 0.879). Conclusion The present study demonstrates that the TAFI levels are elevated in the active state of UC. The assessment of TAFI levels in patients with UC in conjunction with other markers of inflammation may provide additional information for estimating UC activation and severity.