Binding Interaction Between Lauric Acid and Cluster of Differentiation 36 Underpinned by a Fluorescence- Intensifying Assay

Cluster of differentiation 36 (CD36) is a scavenger receptor expressed in various vertebrate cells that contains diverse ligands, including long-chain fatty acids. This receptor has recently been suggested as a captor of specific volatile odorants (e.g., aliphatic acetates) in the mammalian nasal ep...

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Bibliographic Details
Published in:	Journal of Oleo Science Vol. 73; no. 1; pp. 113 - 119
Main Authors:	Tsuzuki, Satoshi, Sugawara, Tatsuya, Manabe, Yuki, Yamasaki, Masayuki, Sasaki, Tsutomu
Format:	Journal Article
Language:	English Japanese
Published:	Tokyo Japan Oil Chemists' Society 2024 Japan Science and Technology Agency
Subjects:	Acetates binding interaction CD36 Clusters Differentiation Fatty acids Fluorescence fluorescence-intensifying assay Lauric acid Ligands odor-active aliphatic compounds Receptors Vertebrates
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Summary:	Cluster of differentiation 36 (CD36) is a scavenger receptor expressed in various vertebrate cells that contains diverse ligands, including long-chain fatty acids. This receptor has recently been suggested as a captor of specific volatile odorants (e.g., aliphatic acetates) in the mammalian nasal epithelium. This study used a fluorescence-intensifying assay to produce the first evidence that lauric acid, an odorous fatty acid, directly binds to CD36. This expansion of the repertoire of volatile ligands supports potential applications for nasal CD36. Our present findings could promote future research aimed at understanding the mechanisms of fatty acid interactions with CD36.
ISSN:	1345-8957 1347-3352
DOI:	10.5650/jos.ess23156