Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma

A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit f...

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Bibliographic Details
Published in:	Diagnostic pathology Vol. 14; no. 1; p. 24
Main Authors:	Przybyl, Joanna, van de Rijn, Matt, Rutkowski, Piotr
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 14-03-2019 BioMed Central BMC
Subjects:	Biopsy Cancer Cancer metastasis Circulating tumor cells (CTCs) Deoxyribonucleic acid DNA DNA methylation EDTA Gene expression Genomes Liquid biopsy Medical research Nested RT-PCR Patients Peripheral blood Polymerase chain reaction RNA Sarcoma SS18-SSX fusion transcript Synovial sarcoma Tumor cells Tumors Poland Nested RT-PCR Liquid biopsy SS18-SSX fusion transcript Circulating tumor cells (CTCs) Synovial sarcoma
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Summary:	A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. However, given the low detection rate of SS18-SSX1/2 in circulation, we conclude that alternative markers other than the tumor-type specific fusion transcripts should be considered.
Bibliography:	SourceType-Other Sources-1 content type line 63 ObjectType-Editorial-2 ObjectType-Commentary-1
ISSN:	1746-1596 1746-1596
DOI:	10.1186/s13000-019-0800-x