A Single Nucleotide Polymorphism in the FADS1 Gene is Associated with Plasma Fatty Acid and Lipid Profiles and Might Explain Gender Difference in Body Fat Distribution

• Published in: Lipids in health and disease Vol. 16; no. 1; p. 67
• Main Authors: Guo, Huilan, Zhang, Lichao, Zhu, Chaonan, Yang, Fei, Wang, Shanshan, Zhu, Shankuan, Ma, Xiaoguang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31-03-2017; BioMed Central; BMC
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alcohol; Alleles; Apolipoproteins; Arachidonic acid; Asian Continental Ancestry Group; Body composition; Body fat; Body Fat Distribution; Cardiovascular disease; China; Cholesterol; Coronary vessels; Deoxyribonucleic acid; Desaturase; desaturase activity; DNA; Docosahexaenoic acid; Dual energy X-ray absorptiometry; Fasting; fat mass; Fat metabolism; fatty acid; Fatty Acid Desaturases - genetics; Fatty acids; Fatty Acids - blood; Female; Gas chromatography; Gender differences; Gene loci; Gene polymorphism; Genetic aspects; Genetic Association Studies; genotype; Genotyping; Health aspects; Humans; Linoleic acid; Lipid metabolism; lipid profiles; Lipids; Lipoproteins; Male; Metabolism; Middle Aged; Minority & ethnic groups; Obesity; Phospholipids; Polymorphism, Single Nucleotide; Population; Public health; Questionnaires; Risk factors; Sex Characteristics; Single nucleotide polymorphisms; Single-nucleotide polymorphism; SNP; Studies; Young Adult; fat distribution; SNP; fat mass; fatty acid; lipid profiles; desaturase activity; genotype
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-017-0459-9

Genotyping of the rs174547 polymorphism in the fatty acid desaturase 1 gene (FADS1) shows that it is associated with the FA composition of plasma phospholipids and lipid metabolic indices among several ethnic groups. However, this association requires further confirmation in the Chinese population, and little is known about the effect of polymorphisms in fatty acid-related genes on body fat distribution.
Anthropometric measurements of 951 Chinese adults aged 18-79 were obtained and body fat distribution was estimated using dual-energy X-ray absorptiometry. The FA composition of plasma phospholipids was measured by gas chromatography. Multiple linear regression assessed whether the rs174547 genotype was associated with FA composition, body fat distribution, and metabolic traits in additive, dominant, and recessive models.
The rs174547 C minor allele was associated with a higher proportion of linoleic acid, lower arachidonic acid and docosahexaenoic acid, as well as lower delta-6-desaturase and delta-5-desaturase activity. Female C allele carriers had lower android fat percentages and lower levels of low-density lipoprotein-cholesterol, while male C allele carriers had lower gynoid fat percentages and higher triglyceride after adjusting for age, income, BMI, behavioral risk factors, and regional fat percentages.
An association of FADS1 rs174547 with the FA composition of plasma phospholipids was identified among this Chinese adult population. The association with body fat distribution and lipid metabolic indices differed between men and women, which might explain sexual differences in body fat distribution and lipid metabolism.