Ultrasonography Echotexture as a surrogate for Sialadenitis secondary to 131I Radioiodine Therapy for differentiated Thyroid Cancer: a review and metaanalysis

• Published in: Clinics (São Paulo, Brazil) Vol. 75; p. e1843
• Main Authors: Lima, Graziele Aparecida Simões, López, Rossana Verónica Mendoza, Ozório, Gislaine Aparecida, de Freitas, Ricardo Miguel Costa, Willegaignon, Jose, Sapienza, Marcelo Tatit, Chammas, Maria Christina, Coura-Filho, George Barberio
• Format: Journal Article
• Language: English
• Published: Brazil Elsevier España, S.L.U 01-01-2020; Faculdade de Medicina / USP; Elsevier España
• Subjects: Differentiated Thyroid Cancer; Humans; Iodine Radioisotopes - adverse effects; Major Salivary Glands; MEDICINE, GENERAL & INTERNAL; Radioiodine; Review; Sialadenitis; Sialadenitis - diagnostic imaging; Sialadenitis - etiology; Thyroid Neoplasms - diagnostic imaging; Thyroid Neoplasms - radiotherapy; Ultrasonography; Sialadenitis; Differentiated Thyroid Cancer; Radioiodine; Major Salivary Glands; Ultrasonography
• ISSN: 1807-5932; 1980-5322; 1980-5322
• DOI: 10.6061/clinics/2020/e1843

To systematically review and analyze the medical literature to assess ultrasonography echotexture changes in thyroid cancer patients for the detection of chronic sialadenitis caused by radioiodine therapy. Methods: Sources were retrieved from PubMed, Scopus, EMBASE and LILACS through November 2018. All studies that assessed ultrasonographic features before 131I administration and at 12 months after 131I administration were selected. After data extraction, statistical analysis was performed by using Stata software. Results: From a total of 435 studies, 4 studies involving 665 patients were considered eligible, and echotexture heterogeneity was found with a significant difference. Conclusions: Ultrasound echotexture may detect chronic sialadenitis secondary to salivary radioiodine therapy.