ThermoTRPs and Pain

The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors. The molecular receptors of noxious mechanical, temperature, or chemical stimuli are expressed in these neurons and have drawn considerable attention as possible targ...

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Bibliographic Details
Published in:	The Neuroscientist Vol. 22; no. 2; pp. 171 - 187
Main Authors:	Laing, Robyn J, Dhaka, Ajay
Format:	Book Review Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-04-2016
Subjects:	Animals Humans Hyperalgesia - genetics Hyperalgesia - physiopathology Models, Molecular Nociceptors - physiology Pain - genetics Physical Stimulation Transient Receptor Potential Channels - physiology thermoTRPs pain TRPA1 TRPV4 analgesia TRPV3 nociception TRPV1 TRPM8 TRPM3
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Summary:	The ability of the body to perceive noxious stimuli lies in a heterogeneous group of primary somatosensory neurons termed nociceptors. The molecular receptors of noxious mechanical, temperature, or chemical stimuli are expressed in these neurons and have drawn considerable attention as possible targets for analgesic development to improve treatment for the millions who suffer from chronic pain conditions. A number of thermoTRPs, a subset of the transient receptor potential family of ion channels, are activated by a wide range on noxious stimuli. In this review, we review the function of these channels and examine the evidence that thermoTRPs play a vital role in acute, inflammatory and neuropathic nociception.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1073-8584 1089-4098
DOI:	10.1177/1073858414567884