Progress in research on paclitaxel and tumor immunotherapy

Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic pathway o...

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Bibliographic Details
Published in:	Cellular & molecular biology letters Vol. 24; no. 1; p. 40
Main Authors:	Zhu, Linyan, Chen, Liqun
Format:	Journal Article
Language:	English
Published:	England BioMed Central 13-06-2019 BMC
Subjects:	Anticancer mechanism Antineoplastic drugs Antitumor agents Biosynthesis Biosynthetic pathway Biotechnology Cancer Cardiovascular disease Cell cycle Chemical synthesis Chromatography Clinical trials Endophytes Endophytic fungus Fermentation Fungi Genetic engineering Immunotherapy Paclitaxel Recombination Review Letter Tumors Anticancer mechanism Biosynthetic pathway Endophytic fungus Paclitaxel
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Summary:	Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic pathway of paclitaxel. With the advancement of biotechnology, improvements in endophytic fungal strains, and the use of recombination techniques and microbial fermentation engineering, the yield of extracted paclitaxel has increased significantly. Recently, paclitaxel has been found to play a large role in tumor immunity, and it has a great potential for use in many cancer treatments.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1425-8153 1689-1392
DOI:	10.1186/s11658-019-0164-y