Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status
Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB)...
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| Published in: | Frontiers in human neuroscience Vol. 14; p. 586998 |
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| Abstract | Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m
(mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin' Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs. |
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| AbstractList | Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m2 (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin’ Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs. Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m2 (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin' Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs.Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m2 (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin' Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs. Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin' Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs. Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m 2 (mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin’ Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs. |
| Author | Hummel, Thomas Poessel, Maria Pampel, André Horstmann, Annette Villringer, Arno Breuer, Nora Joshi, Akshita |
| AuthorAffiliation | 9 International Max Planck Research School on the Neuroscience of Communication, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany 3 Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School , Dresden , Germany 4 Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany 10 Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki , Helsinki , Finland 7 Charité – Universitätsmedizin Berlin , Berlin , Germany 11 Leipzig University Medical Center, Collaborative Research Council (CRC) 1052A5 ‘Obesity Mechanisms’ , Leipzig , Germany 1 Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany 2 Integriertes Forschungs- und Behandlungszentrum (IFB) Adiposity Diseases, Leipzig University Medical Center , Leipzig , Germany 5 Day Clinic for Cognitive Neurology, University Hospital at the University of Leipzig , Lei |
| AuthorAffiliation_xml | – name: 2 Integriertes Forschungs- und Behandlungszentrum (IFB) Adiposity Diseases, Leipzig University Medical Center , Leipzig , Germany – name: 3 Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School , Dresden , Germany – name: 9 International Max Planck Research School on the Neuroscience of Communication, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany – name: 5 Day Clinic for Cognitive Neurology, University Hospital at the University of Leipzig , Leipzig , Germany – name: 8 International Max Planck Research School on the Life Course, Max Planck Institute for Human Development , Berlin , Germany – name: 1 Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany – name: 11 Leipzig University Medical Center, Collaborative Research Council (CRC) 1052A5 ‘Obesity Mechanisms’ , Leipzig , Germany – name: 6 Berlin School of Mind and Brain, Mind Brain Body Institute, Humboldt-Universität zu Berlin , Berlin , German – name: 7 Charité – Universitätsmedizin Berlin , Berlin , Germany – name: 4 Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences , Leipzig , Germany – name: 10 Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki , Helsinki , Finland |
| Author_xml | – sequence: 1 givenname: Maria surname: Poessel fullname: Poessel, Maria organization: Integriertes Forschungs- und Behandlungszentrum (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany – sequence: 2 givenname: Nora surname: Breuer fullname: Breuer, Nora organization: Integriertes Forschungs- und Behandlungszentrum (IFB) Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany – sequence: 3 givenname: Akshita surname: Joshi fullname: Joshi, Akshita organization: Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany – sequence: 4 givenname: André surname: Pampel fullname: Pampel, André organization: Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany – sequence: 5 givenname: Arno surname: Villringer fullname: Villringer, Arno organization: International Max Planck Research School on the Neuroscience of Communication, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany – sequence: 6 givenname: Thomas surname: Hummel fullname: Hummel, Thomas organization: Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany – sequence: 7 givenname: Annette surname: Horstmann fullname: Horstmann, Annette organization: Leipzig University Medical Center, Collaborative Research Council (CRC) 1052A5 'Obesity Mechanisms', Leipzig, Germany |
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| ContentType | Journal Article |
| Copyright | Copyright © 2020 Poessel, Breuer, Joshi, Pampel, Villringer, Hummel and Horstmann. 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2020 Poessel, Breuer, Joshi, Pampel, Villringer, Hummel and Horstmann. 2020 Poessel, Breuer, Joshi, Pampel, Villringer, Hummel and Horstmann |
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| Keywords | HOMA-IR olfaction metabolic health olfactory bulb smell perception obesity |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Hirac Gurden, Université de Paris, France; Debra Ann Fadool, Florida State University, United States; Tara Sankar Roy, All India Institute of Medical Sciences, India This article was submitted to Health, a section of the journal Frontiers in Human Neuroscience These authors have contributed equally to this work and share first authorship Edited by: Suleyman Kaplan, Ondokuz Mayýs University, Turkey |
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| Title | Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status |
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