Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status

• Published in: Frontiers in human neuroscience Vol. 14; p. 586998
• Main Authors: Poessel, Maria, Breuer, Nora, Joshi, Akshita, Pampel, André, Villringer, Arno, Hummel, Thomas, Horstmann, Annette
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 27-11-2020; Frontiers Media S.A
• Subjects: Anatomy; Body fat; Body mass index; Body weight gain; Brain architecture; Diabetes; Eating behavior; Food; HOMA-IR; Insulin; Insulin resistance; Leptin; Magnetic resonance imaging; metabolic health; Metabolism; Neuroimaging; Neuroscience; Obesity; Odor; Olfaction; Olfactory bulb; Olfactory perception; Questionnaires; Smell; smell perception; Vegetarianism; Germany; HOMA-IR; olfaction; metabolic health; olfactory bulb; smell perception; obesity
• ISSN: 1662-5161; 1662-5161
• DOI: 10.3389/fnhum.2020.586998

Smell perception plays an important role in eating behavior and might be involved in body weight gain. Since a body of literature implies that olfactory perception and function is hampered in obesity, we here investigate neuroanatomical correlates of this phenomenon. We assessed olfactory bulb (OB) volume with magnetic resonance imaging in 67 healthy participants with a body mass index (BMI) from 18.9 to 45.4 kg/m
(mean = 28.58 ± 6.64). Moreover, we obtained psychophysiological data on olfactory ability (Sniffin' Sticks, Food associated odor test) and self-report measurements on eating behavior. Additionally, we collected parameters associated with metabolic health in obesity (waist-hip ratio, waist-height ratio, leptin levels, body fat percentage, fat mass index, insulin resistance) to investigate recently proposed mechanistic explanatory models of why olfaction may be altered in obesity. We showed that OB volume was significantly lower in participants with obesity when compared to those of normal weight. Moreover, we found weak to moderate negative correlations between OB volume and BMI and related measures of metabolic health, especially leptin, body fat percentage, waist-height ratio and insulin resistance. However, neither OB volume nor BMI were related to olfactory function in our young and healthy sample. Nevertheless, our results provide first indications that obesity is associated with brain anatomical changes in the OBs.