Within and beyond the stringent response-RSH and (p)ppGpp in plants

• Published in: Planta Vol. 246; no. 5; pp. 817 - 842
• Main Authors: Boniecka, Justyna, Prusińska, Justyna, Dabrowska, Grażyna B., Goc, Anna
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Science + Business Media 01-11-2017; Springer Berlin Heidelberg; Springer Nature B.V
• Subjects: Accumulation; Adaptation; Adaptation, Physiological; Agriculture; Algae; Arabidopsis - enzymology; Arabidopsis - genetics; Arabidopsis - growth & development; Bacteria; Biomedical and Life Sciences; Chloroplast DNA; Chloroplasts; Chloroplasts - metabolism; Cytoplasm; Deoxyribonucleic acid; Deprivation; DNA; DNA biosynthesis; Ecology; Forestry; Gene expression; Guanosine; Guanosine Pentaphosphate - metabolism; Homology; Life Sciences; Ligases - genetics; Ligases - metabolism; Metabolism; Metabolites; Nuclei; Nucleotides; Nutrient deficiency; Photosynthesis; Plant Development; Plant growth; Plant Proteins - genetics; Plant Proteins - metabolism; Plant Sciences; Plant viruses; Plants (botany); Plants - enzymology; Plants - genetics; Proteins; RelA protein; Relocation; Replication; REVIEW; Seeds; Senescence; Spot; Stress, Physiological; Stresses; Stringent response; Transcription; Translation; Viruses; RelA/SpoT homologs; Plant growth and development; Senescence; Stress response; Photosynthesis; Alarmones
• ISSN: 0032-0935; 1432-2048
• DOI: 10.1007/s00425-017-2780-y

Homologs of bacterial RelA/SpoT proteins, designated RSH, and products of their activity, (p)ppGpp—guanosine tetra—and pentaphosphates, have been found in algae and higher plants. (p)ppGpp were first identified in bacteria as the effectors of the stringent response, a mechanism that orchestrates pleiotropic adaptations to nutritional deprivation and various stress conditions. (p)ppGpp accumulation in bacteria decreases transcription—with exception to genes that help to withstand or overcome current stressful situations, which are upregulated—and translation as well as DNA replication and eventually reduces metabolism and growth but promotes adaptive responses. In plants, RSH are nuclei-encoded and function in chloroplasts, where alarmones are produced and decrease transcription, translation, hormone, lipid and metabolites accumulation and affect photosynthetic efficiency and eventually plant growth and development. During senescence, alarmones coordinate nutrient remobilization and relocation from vegetative tissues into seeds. Despite the high conservancy of RSH protein domains among bacteria and plants as well as the bacterial origin of plant chloroplasts, in plants, unlike in bacteria, (p)ppGpp promote chloroplast DNA replication and division. Next, (p)ppGpp may also perform their functions in cytoplasm, where they would promote plant growth inhibition. Furthermore, (p) ppGpp accumulation also affects nuclear gene expression, i.a., decreases the level of Arabidopsis defense gene transcripts, and promotes plants susceptibility towards Turnip mosaic virus. In this review, we summarize recent findings that show the importance of RSH and (p)ppGpp in plant growth and development, and open an area of research aiming to understand the function of plant RSH in response to stress.