Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis

• Published in: Clinical and experimental immunology Vol. 134; no. 1; pp. 138 - 142
• Main Authors: D’AGOSTINO, P., CAMEMI, A. RAO, CARUSO, R., ARCOLEO, F., CASCIO, A., DOLCE, A., SACCO, E., CANGEMI, G., ROSA, T. DI, MOCEO, P., CILLARI, E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01-10-2003; Blackwell; Oxford University Press; Blackwell Science Inc
• Subjects: a-1 antitrypsin; Aged; alpha 1-Antitrypsin - analysis; alpha 1-Antitrypsin - metabolism; Biological and medical sciences; C-Reactive Protein - analysis; C-Reactive Protein - metabolism; Clinical Studies; Female; Humans; Male; malignant pleural effusions; Matrix Metalloproteinase 1 - analysis; Matrix Metalloproteinase 1 - metabolism; Matrix Metalloproteinase 9 - analysis; Matrix Metalloproteinase 9 - metabolism; matrix metalloproteinases; Matrix Metalloproteinases - metabolism; Medical sciences; Middle Aged; Plasminogen - analysis; Plasminogen - metabolism; Pleural Effusion, Malignant - enzymology; Pleural Effusion, Malignant - immunology; Pleural Effusion, Malignant - therapy; Pleurodesis; Pneumology; Statistics, Nonparametric; Talc - administration & dosage; talc pleurodesis; Tissue Inhibitor of Metalloproteinase-1 - analysis; Tissue Inhibitor of Metalloproteinase-1 - metabolism; Tumors of the respiratory system and mediastinum; Human; Talc; Enzyme; malignant pleural effusions matrix metalloproteinases talc pleurodesis; Metalloendopeptidases; Pleurodesis; Peptidases; Treatment; Malignant effusion; Hydrolases; Synechia; Pleural fluid; Pleura
• ISSN: 0009-9104; 1365-2249
• DOI: 10.1046/j.1365-2249.2003.02262.x

SUMMARY
In this study we have evaluated the modifications of matrix metalloproteinases (MMPs) in malignant pleural fluids taken from patients suffering from lung cancer and treated with intrapleural talc instillation to induce pleurodesis. Furthermore, we have analysed the variations of some inflammatory mediators (C‐reactive protein, α‐1 antitrypsin) and of a protein (plasminogen) involved in MMP activation. In all patients the clinical improvement after talc pleurodesis was followed by a reduction in MMP‐1, TIMP‐1, C‐reactive protein, α‐1 antitrypsin and plasminogen activity. Furthermore, MMP‐9 levels were variable; in fact, in some patients they were high at the beginning of treatment, in others they increased a few days after pleurodesis induction. These inhibitory effects of talc on MMP‐1 and inflammatory mediators associated with the reduction of pleural effusion could constitute an effective means to evaluate the evolution of the treatment.