Immunologic Analysis of a Spinal Cord–Biopsy Specimen from a Patient with Human T-Cell Lymphotropic Virus Type I–Associated Neurologic Disease

Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia and a chronic progressive neurologic disease, HTLV-I–associated myelopathy–tropical spastic paraparesis (hereafter referred to as HTLV-I–associated myelopathy). 1 – 5 HTVL-I is endemic in Japan, the Caribbean, A...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 336; no. 12; pp. 839 - 845
Main Authors:	Levin, Michael C, Lehky, Tanya J, Flerlage, Alfred N, Katz, David, Kingma, Douglas W, Jaffe, Elaine S, Heiss, John D, Patronas, Nicholas, McFarland, Henry F, Jacobson, Steven
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 20-03-1997
Subjects:	AIDS/HIV Biological and medical sciences Biopsy CD8-Positive T-Lymphocytes Cells Cerebrospinal Fluid - virology Disease Female human T-lymphotropic virus 1 Human viral diseases Humans Immunity (Disease) Immunohistochemistry Infectious diseases Macrophages Magnetic Resonance Imaging Medical sciences Middle Aged Paraparesis, Tropical Spastic - immunology Paraparesis, Tropical Spastic - pathology Paraparesis, Tropical Spastic - virology Spinal cord Spinal Cord - immunology Spinal Cord - pathology Viral diseases Viral diseases of the nervous system Viral Load Human Immunohistochemistry Nervous system diseases Retroviridae Exploration Infection Virus Case study Pathology Myelopathy Biopsy Viral disease Central nervous system disease HTLV-I virus Spinal cord disease
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Summary:	Human T-cell lymphotropic virus type I (HTLV-I) is associated with adult T-cell leukemia and a chronic progressive neurologic disease, HTLV-I–associated myelopathy–tropical spastic paraparesis (hereafter referred to as HTLV-I–associated myelopathy). 1 – 5 HTVL-I is endemic in Japan, the Caribbean, Africa, and South America. 5 Risk factors for infection include sexual contact, exchange of blood products, and vertical transmission from mother to child. 5 HTLV-I–associated myelopathy causes progressive myelopathy with atrophy of the spinal cord. 5 , 6 Subcortical white-matter lesions are sometimes present on magnetic resonance imaging. 5 – 7 Cerebrospinal fluid shows pleocytosis, elevated titers of IgG, and oligoclonal bands. 8 – 10 Autopsy results correlate with neurologic findings . . .
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Case Study-2 ObjectType-Feature-4 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM199703203361205