Daily electrical activity in the master circadian clock of a diurnal mammal

Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active...

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Bibliographic Details
Published in:	eLife Vol. 10
Main Authors:	Bano-Otalora, Beatriz, Moye, Matthew J, Brown, Timothy, Lucas, Robert J, Diekman, Casey O, Belle, Mino Dc
Format:	Journal Article
Language:	English
Published:	England eLife Science Publications, Ltd 30-11-2021 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Subjects:	Analysis Animals B cells Circadian Clocks - physiology Circadian rhythm Circadian rhythms Computational and Systems Biology Diurnal diurnality electrical activity Labeling mathematical modelling Mathematical models Muridae - physiology Neurons Neurons - physiology Neuropeptides Neurophysiology Neuroscience Nocturnal Peptides Physiology Potassium channels Rhabdomys pumilio suprachiasmatic nucleus Suprachiasmatic Nucleus - physiology United Kingdom computational biology systems biology mathematical modelling neuroscience diurnality electrical activity circadian rhythms suprachiasmatic nucleus
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Summary:	Circadian rhythms in mammals are orchestrated by a central clock within the suprachiasmatic nuclei (SCN). Our understanding of the electrophysiological basis of SCN activity comes overwhelmingly from a small number of nocturnal rodent species, and the extent to which these are retained in day-active animals remains unclear. Here, we recorded the spontaneous and evoked electrical activity of single SCN neurons in the diurnal rodent , and developed cutting-edge data assimilation and mathematical modeling approaches to uncover the underlying ionic mechanisms. As in nocturnal rodents, SCN neurons were more excited during daytime hours. By contrast, the evoked activity of neurons included a prominent suppressive response that is not present in the SCN of nocturnal rodents. Our modeling revealed and subsequent experiments confirmed transient subthreshold A-type potassium channels as the primary determinant of this response, and suggest a key role for this ionic mechanism in optimizing SCN function to accommodate 's diurnal niche.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	2050-084X 2050-084X
DOI:	10.7554/elife.68179