Development of Common Data Elements for Use in Chiari Malformation Type I Clinical Research: An NIH/NINDS Project

• Published in: Neurosurgery Vol. 85; no. 6; pp. 854 - 860
• Main Authors: Luciano, Mark G, Batzdorf, Ulrich, Kula, Roger W, Rocque, Brandon G, Maher, Cormac O, Heiss, John, Martin, Bryn A, Bolognese, Paolo A, Ashley-Koch, Allison, Limbrick, David, Poppe, Dorothy J, Esposito, Kaitlyn M, Odenkirchen, Joanne, Esterlitz, Joy R, Ala’i, Sherita, Joseph, Kristen, Feldman, Robin S, Riddle, Robert
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01-12-2019; Copyright by the Congress of Neurological Surgeons; Wolters Kluwer Health, Inc
• Subjects: Arnold-Chiari Malformation - diagnostic imaging; Arnold-Chiari Malformation - epidemiology; Arnold-Chiari Malformation - therapy; Biomedical Research - standards; Biomedical Research - trends; Care and treatment; Clinical trials; Common Data Elements; Data dictionaries; Editor's Choice; Health Personnel - standards; Health Personnel - trends; Humans; Information sharing; Medical research; Medicine, Experimental; National Institute of Neurological Disorders and Stroke (U.S.) - standards; National Institute of Neurological Disorders and Stroke (U.S.) - trends; Nervous system diseases; Neurosurgery; Outcome Assessment, Health Care - standards; Outcome Assessment, Health Care - trends; Retrospective Studies; Special; United States - epidemiology; United States; Maryland; Massachusetts; Chiari Malformation; Common Data Elements
• ISSN: 0148-396X; 1524-4040
• DOI: 10.1093/neuros/nyy475

ABSTRACT
The management of Chiari I malformation (CMI) is controversial because treatment methods vary and treatment decisions rest on incomplete understanding of its complex symptom patterns, etiologies, and natural history. Validity of studies that attempt to compare treatment of CMI has been limited because of variable terminology and methods used to describe study subjects. The goal of this project was to standardize terminology and methods by developing a comprehensive set of Common Data Elements (CDEs), data definitions, case report forms (CRFs), and outcome measure recommendations for use in CMI clinical research, as part of the CDE project at the National Institute of Neurological Disorders and Stroke (NINDS) of the US National Institutes of Health. A working group, comprising over 30 experts, developed and identified CDEs, template CRFs, data dictionaries, and guidelines to aid investigators starting and conducting CMI clinical research studies. The recommendations were compiled, internally reviewed, and posted online for external public comment. In October 2016, version 1.0 of the CMI CDE recommendations became available on the NINDS CDE website. The recommendations span these domains: Core Demographics/Epidemiology; Presentation/Symptoms; Co-Morbidities/Genetics; Imaging; Treatment; and Outcome. Widespread use of CDEs could facilitate CMI clinical research trial design, data sharing, retrospective analyses, and consistent data sharing between CMI investigators around the world. Updating of CDEs will be necessary to keep them relevant and applicable to evolving research goals for understanding CMI and its treatment.