Cepacin A and cepacin B, two new antibiotics produced by Pseudomonas cepacia

• Published in: Journal of antibiotics Vol. 37; no. 5; p. 431
• Main Authors: Parker, W L, Rathnum, M L, Seiner, V, Trejo, W H, Principe, P A, Sykes, R B
• Format: Journal Article
• Language: English
• Published: Japan 1984
• Subjects: Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Fermentation; Lactones - isolation & purification; Lactones - pharmacology; Magnetic Resonance Spectroscopy; Molecular Conformation; Pseudomonas - metabolism; Spectrophotometry, Ultraviolet
• ISSN: 0021-8820
• DOI: 10.7164/antibiotics.37.431

Two new acetylenic antibiotics, cepacins A and B, have been isolated from the fermentation broth of Pseudomonas cepacia SC 11,783 and assigned structures 1 and 2. Cepacin A has good activity against staphylococci (MIC 0.2 micrograms/ml) but weak activity against streptococci (MIC 50 micrograms/ml) and the majority of Gram-negative organisms (MIC values 6.3 approximately greater than 50 micrograms/ml). Cepacin B has excellent activity against staphylococci (MIC less than 0.05 micrograms/ml) and some Gram-negative organisms (MIC values 0.1 approximately greater than 50 micrograms/ml).