Prognostic value of CSN5 in patients with digestive system cancers: a systematic review and meta-analysis

• Published in: BMC cancer Vol. 22; no. 1; pp. 1 - 812
• Main Authors: Guo, Yonghua, Gao, Meng, Yao, Ye, Li, Jinghua, Chen, Xi, Wang, Xingxing, Chen, Zhang, Yuan, Yufeng, Ma, Weijie
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 23-07-2022; BioMed Central; BMC
• Subjects: Analysis; Binding sites; Cancer; Cohort analysis; Colorectal cancer; CSN5; Digestive system; Digestive system cancer; Esophageal cancer; Gastric cancer; Jab1; Liver cancer; Medical prognosis; Meta-analysis; Metastases; Metastasis; Prognosis; Proteins; Signal transduction; Software; Survival; Survival analysis; Systematic review; Tumor markers; Tumors; China
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-022-09867-9

Background Despite the understanding of the COP9 signalosome subunit 5 (CSN5) in tumor genesis, there is no conclusive evidence on its value to predict the survival and prognosis of digestive system tumor patients. Hence this study aimed to evaluate the impact of CSN5 levels on the survival and clinicopathological parameters of digestive system neoplasm patients. Methods First, a comprehensive search was conducted in four databases. We utilized the Hazard Ratio (HR) with a 95% confidence interval (CI) to evaluate the prognostic value of CSN5 for the overall survival (OS) and recurrence-free survival (RFS) of patients. Then, we estimated the connection between CSN5 and the clinicopathological parameters based on the Odds Ratio (OR) with the corresponding 95% CI. Results This meta-analysis included 22 studies and 2193 patients diagnosed with digestive system tumors. High expression of CSN5 was correlated to poorer OS (HR = 2.28, 95% CI: 1.71-3.03; p < 0.00001). Additionally, high CSN5 levels were correlated with worse invasion depth (OR = 0.49, 95% CI: 0.25-0.96, p = 0.04), positive lymphatic metastasis (OR = 0.28, 95% CI: 0.16-0.47, p = 0.00001), positive distant metastasis (OR = 0.32, 95% CI: 0.13-0.76, p = 0.01) and poorer differentiation degree (OR = 0.34, 95% CI: 0.19-0.60, p = 0.0003). However, we did not detect a correlation between CSN5 expression and age, gender, tumor stage, tumor size or vascular invasion. Furthermore, no significant publication bias was detected. Conclusion This meta-analysis demonstrated that the overexpression of CSN5 level might foresee poorer OS in digestive system cancer patients. Additionally, CSN5 levels might be related to the prognosis of digestive system tumors. Keywords: Jab1, CSN5, Cancer, Digestive system, Meta-analysis