A Prospective Study of New Infections with Herpes Simplex Virus Type 1 and Type 2

• Published in: The New England journal of medicine Vol. 341; no. 19; pp. 1432 - 1438
• Main Authors: Langenberg, Andria G.M, Corey, Lawrence, Ashley, Rhoda L, Leong, Wai Ping, Straus, Stephen E
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 04-11-1999
• Subjects: Acquisitions & mergers; Biological and medical sciences; Confidence intervals; Herpes simplex virus 1; Herpes simplex virus 2; Human viral diseases; Immunization; Infections; Infectious diseases; Medical sciences; Sexually transmitted diseases; STD; Vaccines; Viral diseases; Viral diseases of the genital and urinary system; Human; Herpesviridae; Alphaherpesvirinae; Glycoprotein; Prediction; Vaccine; Infection; Virus; Efficiency; Cohort study; Viral disease; Value; Herpesvirus hominis; Diagnosis
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199911043411904

Herpes simplex virus (HSV) infections are endemic throughout the world.
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In both point-prevalence and prospective studies, a large percentage of persons who are seropositive for HSV type 1 (HSV-1) or HSV type 2 (HSV-2) have no clinical manifestations of the disease.
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Many of the clinical characteristics of symptomatic genital HSV are similar to those of other conditions, such as nongonococcal urethritis in men,
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nonchlamydial urethritis
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and recurrent vaginitis
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in women, and neurologic diseases, including aseptic meningitis.
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No studies have prospectively defined the relative frequency of symptomatic or asymptomatic HSV infection and the relative proportions of typical . . .